Dendritic GIRK Channels Gate the Integration Window, Plateau Potentials, and Induction of Synaptic Plasticity in Dorsal But Not Ventral CA1 Neurons
Dendritic GIRK Channels Gate the Integration Window, Plateau Potentials, and Induction of Synaptic Plasticity in Dorsal But Not Ventral CA1 Neurons
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DOI：
10.1523/jneurosci.2784-16.2017
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发表时间：
2017-04-05
影响因子：
5.3
通讯作者：
Johnston, Daniel
中科院分区：
文献类型：
--
作者：
Malik, Ruchi;Johnston, Daniel
比较海马体背极和腹极神经元活动的研究表明，从背端到腹端，空间信息的规模增加，空间表示的精确度下降。这些背腹侧的神经元输出和空间表示的差异可能会出现由于背侧和腹侧CA1神经元执行的计算的差异。在这项研究中，我们测试了这一假设，通过量化的差异树突整合和突触可塑性之间的背侧和腹侧海马CA1区锥体神经元。使用体细胞和树突膜片钳记录相结合，我们表明，LTP诱导的阈值较高，背侧CA1神经元和G蛋白偶联内向整流钾通道介导的调节树突平台电位和树突兴奋性的基础上，这个门控。相比之下，腹侧CA1神经元中不存在类似的LTP调节。此外，我们表明，在背侧CA1神经元的平台电位和LTP诱导的产生依赖于同时激活的谢弗侧支和temporoammonic输入在远端顶端树突。腹侧CA1树突，然而，可以产生高原电位响应时间分散的兴奋性输入。总体而言，我们的结果强调了树枝计算中的背腹差异，这可以解释空间表征中的背腹差异。
Studies comparing neuronal activity at the dorsal and ventral poles of the hippocampus have shown that the scale of spatial information increases and the precision with which space is represented declines from the dorsal to ventral end. These dorsoventral differences in neuronal output and spatial representation could arise due to differences in computations performed by dorsal and ventral CA1 neurons. In this study, we tested this hypothesis by quantifying the differences in dendritic integration and synaptic plasticity between dorsal and ventral CA1 pyramidal neurons of rat hippocampus. Using a combination of somatic and dendritic patch-clamp recordings, we show that the threshold for LTP induction is higher in dorsal CA1 neurons and that a G-protein-coupled inward-rectifying potassium channel mediated regulation of dendritic plateau potentials and dendritic excitability underlies this gating. By contrast, similar regulation of LTP is absent in ventral CA1 neurons. Additionally, we show that generation of plateau potentials and LTP induction in dorsal CA1 neurons depends on the coincident activation of Schaffer collateral and temporoammonic inputs at the distal apical dendrites. The ventral CA1 dendrites, however, can generate plateau potentials in response to temporally dispersed excitatory inputs. Overall, our results highlight the dorsoventral differences in dendritic computation that could account for the dorsoventral differences in spatial representation.