Familial correlations, segregation analysis, and nongenetic correlates of soy isoflavone-metabolizing phenotypes
Familial correlations, segregation analysis, and nongenetic correlates of soy isoflavone-metabolizing phenotypes
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DOI：
10.1177/153537020422900906
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发表时间：
2004-10-01
影响因子：
3.2
通讯作者：
Lampe, JW
中科院分区：
文献类型：
--
作者：
Frankenfeld, CL;Atkinson, C;Lampe, JW
特定的肠道细菌将大豆异黄酮大豆代谢为雌激素和o-甲基血素素（O-DMA），可以在尿液中鉴定出来的代谢产物。携带能够产生,、或O-DMA的细菌的个体被称为雌性生产者（约占人口的30％-50％）和O-DMA生产者（约占人口的80％-90％）。在几项研究中，雌激素的表型与性激素相关的结局已与性激素相关。但是，尚未确定负责这些表型的细菌，影响这些表型表现的因素尚不清楚。为了评估与这些表型相关的家族聚类和非核因子的聚类，来自112个家庭的410名参加了表型（3天大豆挑战和第4天的尿液收集）。在对雌激素表型的隔离分析中，孟德尔的主要模型为数据提供了最简约的拟合，这表明雌激素表型的遗传模式与常染色体优势性状一致。该表型与教育呈正相关（P趋势= 0.01），但与性，吸烟或几个饮食因素无关。 O-DMA-ragrounucer表型的隔离分析的结果尚无定论。与一般模型相比，没有其他模型为数据提供更简单的拟合。该表型与非线性模型中的年龄成反比（P = 0.01），与年龄和性调整的高度正相关（优势比[OR] 10 cm = 0.38，95％置信区间[CI] = 0.15，= 0.15， 0.95）和体重指数（kg/m（2））（OR = 0.91，95％CI = 0.85，0.96），但不为性别教育，吸烟或几个饮食因素。这些结果表明，雌激素的表型可能处于一定程度的遗传控制下，并且在本分析中可能未评估其他环境因素会导致这两种表型。这些结果为进一步的工作奠定了基础，以完善我们对大泽蛋白 - 代谢表型的可遗传和环境决定因素的理解。
Particular intestinal bacteria metabolize the soy isoflavone daidzein to equol and O-desmethylangolensin (O-DMA), metabolites that can be identified in urine. Individuals that harbor bacteria capable of producing equol or O-DMA are known as equol producers (approximately 30%-50% of the population) and O-DMA producers (approximately 80%-90% of the population), respectively. The equol-producer phenotype has been associated with sex hormone-related outcomes in several studies. However, the bacteria responsible for these phenotypes have not yet been identified and factors that influence the manifestation of these phenotypes are not well understood. To evaluate familial clustering of and nongenetic factors associated with these phenotypes, 410 individuals from 112 families participated in phenotyping (3-day soy challenge and Day 4 spot urine collection). In segregation analyses of the equol-producer phenotype, the Mendelian dominant model provided the most parsimonious fit to the data, suggesting that the pattern of inheritance of the equol-producer phenotype is consistent with an autosomal dominant trait. This phenotype was positively associated with education (p trend = 0.01), but not with sex, smoking, or several dietary factors. Results of the segregation analyses of the O-DMA-producer phenotype were inconclusive; no other models provided a more parsimonious fit to the data than the general model. This phenotype was inversely associated with age in a nonlinear model (p = 0.01), positively associated with age- and sex-adjusted height (odds ratio [OR] 10-cm increase = 0.38, 95% confidence interval [CI] = 0.15, 0.95) and body mass index (kg/m(2)) (OR = 0.91, 95% CI = 0.85, 0.96), but not with sex, education, smoking, or several dietary factors. These results suggest the equol-producer phenotype may be under some degree of genetic control and that there are likely other environmental factors not evaluated in the present analysis that contribute to both of these phenotypes. These results provide a foundation for further work to refine our understanding of heritable and environmental determinants of daidzein-metabolizing phenotypes.