Metered-dose inhaler adherence in a clinical trial.
Metered-dose inhaler adherence in a clinical trial.
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临床试验中计量吸入器的依从性。
DOI：
10.1164/ajrccm/146.6.1559
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Tashkin,DP
中科院分区：
文献类型：
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作者：
Rand,CS;Wise,RA;Nides,M;Simmons,MS;Bleecker,ER;Kusek,JW;Li,VC;Tashkin,DP
在肺健康研究临床试验中，我们研究了来自两个中心的参与者的吸入器使用模式。这种吸入器含有异丙托溴铵或安慰剂，处方是每天三次，分两次服用。在4个月中，我们通过自我报告(n=95)和罐体重量改变(n=70)来记录依从性。我们将这些结果与微处理器监测设备雾化器计时器(NC)获得的数据进行了比较，后者记录了每次吸入器启动的日期和时间。73%的参与者报告平均每天使用吸入器三次；然而，NC数据显示，只有15%的参与者实际上平均每天使用吸入器2.5次或更多。药筒重量高估了依从性，因为只有62%的NC包含规定的两个驱动。14%的人在一段时间内吸入器的动作次数超过100次。
We studied patterns of inhaler usage in a sample of participants from two centers in the Lung Health Study clinical trial. The inhaler, containing either ipratropium bromide or a placebo, was prescribed to be taken as two Inhalations three times daily. For 4 months we recorded adherence by both self-report (n= 95) and canister weight change (n= 70). Wecompared these results with data obtained from a microprocessor monitoring device, the Nebulizer Chronolog (NC), which records the date and time of each inhaler actuation. Seventy-three percent ofthe participants reported using the inhaler an average of three times daily; however, NC data showed that only 15% of the participants actually used the inhaler an average of 2.5 or more times per day. Canister weight overestimated adherence because only 62% of the NCsets contained the prescribed two actuations. Fourteen percent showed a pattern of actuation of their inhalers more than 100times in a ah interval.