Crystal structure of the human laminin receptor precursor
Crystal structure of the human laminin receptor precursor
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DOI：
10.1074/jbc.c700206200
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发表时间：
2008-02-08
影响因子：
4.8
通讯作者：
Meruelo, Daniel
中科院分区：
文献类型：
--
作者：
Jamieson, Kelly V.;Wu, Jinhua;Meruelo, Daniel
人层粘连蛋白受体(LAMR)与许多配体相互作用，包括层粘连蛋白、普恩、Sindbis病毒和多酚(-)-表没食子儿茶素没食子酸酯(EGCG)，并与许多疾病有关。LAMR在肿瘤细胞上过表达，靶向LAMR可产生抗癌作用。在这里，我们报告了人类LAMR的晶体结构，这提供了对其功能的见解，并将促进针对LAMR的新型治疗药物的设计。
The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR.