MR monitoring of MR-guided radiofrequency thermal ablation of normal liver in an animal model
MR monitoring of MR-guided radiofrequency thermal ablation of normal liver in an animal model
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DOI：
10.1002/jmri.1880080115
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Haaga, JR
中科院分区：
文献类型：
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作者：
Boaz, TL;Lewin, JS;Haaga, JR
为了确定MRI是否适合准确检测在MR引导下产生的射频(RF)热消融损伤，本研究使用直径2 mm的钛Ahoy射频电极和50W射频发生器在6只新西兰大白兔的肝脏中创建了射频损伤。这是使用0.2T临床C臂磁共振成像仪进行指导和监测。处死每只动物，进行大体评价。对前两只动物进行组织学对比，在用于指导电极放置的快速梯度回波图像上很容易识别与ME兼容的射频电极。在每只兔的肝脏中创建一个单独的病变。病变直径约为10-17 mm(平均13.5 mm)，T2加权和短T1反转恢复(STIR)图像显示病变直径为12-18 mm(平均14.6 mm)，由图像确定的病变大小与肉眼检查确定的大小密切相关，偏差不超过2 mm，r(2)值为0.87。在MR引导射频消融时进行的MRI准确地显示了所产生的病变。这种方法可能为局部和区域性肿瘤的治疗提供一种新的选择。
The purpose of this study was to determine the suitability of MRI to accurately detect radiofrequency (RF) thermoablative lesions created under MR guidance, In vivo RF lesions were created in the Livers of six New Zealand White rabbits using a 2-mm-diameter titanium ahoy RF electrode with a 20-mm exposed tip and a 50-W RF generator. This was performed using a 0.2T clinical C-arm MR imager for guidance and monitoring. Each animal was sacrificed and gross evaluation was performed. Histologic correlation was performed on the first two animals, The ME-compatible RF electrode was easily identified on rapid gradient-echo images used to guide electrode placement. a single lesion was created in each rabbit liver. Lesions ranged from approximately 10 to 17 mm in diameter (mean, 13.5 mm), T2-weighted and short T1 inversion recovery (STIR) images demonstrated lesions ranging in diameter from 12 to 18 mm (mean, 14.6 mm), Lesion dimensions determined from images closely correlated with those determined at gross examination with the discrepancy never exceeding 2 mm, for an r(2) value of .87. MRI performed at the time of MR-guided RF ablation accurately demonstrated created lesions. This modality may provide a new option for the treatment of local and regional neoplastic disease.