MEDIASTINAL METASTASES IN BRONCHOGENIC-CARCINOMA - INFLUENCE OF POSTOPERATIVE IRRADIATION, CELL TYPE, AND LOCATION
MEDIASTINAL METASTASES IN BRONCHOGENIC-CARCINOMA - INFLUENCE OF POSTOPERATIVE IRRADIATION, CELL TYPE, AND LOCATION
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DOI：
10.1016/s0003-4975(10)60786-2
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发表时间：
1982-01-01
影响因子：
4.6
通讯作者：
SLOAN, H
中科院分区：
文献类型：
--
作者：
KIRSH, MM;SLOAN, H
本文报告了136例肺癌和纵隔转移患者17年的治疗经验。术后死亡6例。110例根治性切除后有肿瘤转移至纵隔淋巴结的患者接受了纵隔放射治疗。其余20名患者没有接受放射治疗。在136例患者中，29例(21.3%)无病存活5年，9例存活10年或以上。在110例手术和放疗后存活的患者中，29例(26.4%)存活了5年。未接受放射治疗的20名患者无一存活5年。在接受放射治疗的患者中，50名鳞癌患者中有18名存活了5年；55名腺癌患者中只有7名存活了5年。肺癌纵隔淋巴结受累可能不是肺切除的禁忌症。与以前的报告一样，组织学细胞类型已被证明是绝对存活的重要指标。鳞癌患者的5年绝对存活率为33.9%；腺癌患者的绝对存活率为12.3%。淋巴结转移程度对预后也有影响。隆突下淋巴结转移的患者的存活率低于上纵隔转移的患者。
A 17-yr experience with 136 patients with bronchogenic carcinoma and mediastinal metastases is reported. Six died postoperatively. Postoperative mediastinal irradiation was given to 110 patients surviving curative resection who had evidence of tumor spreading to the mediastinal lymph nodes. The remaining 20 patients did not receive radiation therapy. Of the 136 patients, 29 (21.3%) lived 5 yr free from disease; 9 survived 10 or more yr. Of the 110 patients who survived operation and underwent irradiation, 29 (26.4%) survived 5 yr. None of the 20 patients not receiving radiation therapy lived 5 yr. Of the patients who underwent irradiation, 18 of the 50 patients with squamous cell carcinoma survived 5 yr; only 7 of 55 with adenocarcinoma survived 5 yr. The discovery of mediastinal lymph node involvement in bronchogenic carcinoma probably is not a contraindication to pulmonary resection. As in previous reports, histological cell type has proved to be an important indicator of absolute survival. Patients with squamous cell carcinoma had an absolute 5-yr survival of 33.9%; the patients with adenocarcinoma has an absolute survival of 12.3%. The level of lymph node metastasis has an influence on prognosis as well. Patients with subcarinal lymph node metastases had a lower survival than patients with superior mediastinal involvement.