Intratympanic steroid therapy for inner ear diseases, a review of the literature
Intratympanic steroid therapy for inner ear diseases, a review of the literature
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DOI：
10.1007/s00405-006-0065-3
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发表时间：
2006-09-01
影响因子：
2.6
通讯作者：
Stokroos, R. J.
中科院分区：
文献类型：
--
作者：
Alles, M. J. R. C.;Gaag, M. A. der;Stokroos, R. J.
评价鼓室内类固醇治疗梅尼埃病（MD）、特发性突发性感音神经性听力损失（ISSNHL）和快速进行性感音神经性听力损失（RPSNHL）的临床试验价值。检索自1966年至今的Medline和Pubmed数据库，查找MD、ISSNHL和RPSNHL的鼓膜内或鼓膜外类固醇治疗的临床研究。结果与其他数据库交叉核对，以获得完整的数据集。根据可比性、内部效度和外部效度对临床试验进行评价。文章通过以下问题进行评判：是否进行了随机双盲对照试验？MD、ISSNHL、RPSNHL的确诊标准是什么？评估了哪种治疗方法？随访多长时间？使用哪些标准来评估结果？关于MD、ISSNHL和RPSNHL的鼓内类固醇治疗的效率、最佳剂量和给药方案缺乏可靠的证据，因此需要进一步的研究。
To evaluate the value of clinical trials on intratympanic steroid therapy in Meniere's disease (MD), idiopathic sudden sensorineural hearing loss (ISSNHL) and rapidly progressive sensorineural hearing loss (RPSNHL). Medline and Pubmed databases from 1966 to present were searched for clinical studies on intra- or transtympanic (cortico)steroid therapy of MD, ISSNHL and RPSNHL. Results were cross-checked with additional databases to obtain a complete data set. Clinical trials were evaluated on the basis of comparability, internal and external validity. Articles were judged using the following questions: was a randomised double-blind controlled trial performed? Which criteria were used to confirm the diagnosis of MD, ISSNHL, RPSNHL? Which therapy was evaluated? How long was the follow-up? Which criteria were used to evaluate the results? Reliable evidence on the efficiency, optimum dosage and administration schedule of intratympanic steroid therapy in MD, ISSNHL and RPSNHL is lacking, therefore further investigation is required.