Assessing Mild Cognitive Impairment with Amyloid and Dopamine Terminal Molecular Imaging
Assessing Mild Cognitive Impairment with Amyloid and Dopamine Terminal Molecular Imaging
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DOI：
10.2967/jnumed.112.112599
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发表时间：
2013-06-01
影响因子：
9.3
通讯作者：
Frey, Kirk A.
中科院分区：
文献类型：
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作者：
Albin, Roger L.;Burke, James F.;Frey, Kirk A.
我们评估了基于pet的轻度认知障碍（MCI）神经退行性病理分类。方法：我们的研究是一项横断面和前瞻性评估，来自一所大学认知障碍诊所的27名MCI受试者。我们比较了临床专家对初入期MCI和随访时可能出现的痴呆的共识分类与基于分子成像的分类，采用c -11-二氢四苯那嗪PET测量纹状体多巴胺末端完整性和c -11-匹兹堡化合物B (C-11-PiB) PET测量脑淀粉样蛋白负荷。结果：11名受试者被临床初步归类为遗忘型轻度认知损伤，7名为多域轻度认知损伤，9名为非遗忘型轻度认知损伤。在平均3年的随访中，18名受试者转变为痴呆症。PET成像证据表明明显的脑淀粉样蛋白沉积或黑质纹状体去神经支配是转化为痴呆的一个强有力的预测因素。专家临床分类和基于pet的痴呆亚型分类之间只有适度的一致性。结论：脑淀粉样蛋白负荷和纹状体多巴胺末端完整性的PET联合分子成像可能有助于识别进展为痴呆的高风险受试者和定义MCI受试者的神经化学分化亚群。
We evaluated PET-based classification of neurodegenerative pathology in mild cognitive impairment (MCI). Methods: Our study was a cross-sectional and prospective evaluation of a cohort of 27 MCI subjects drawn from a university-based cognitive disorders clinic. We compared expert clinical consensus classification of MCI at entry and possible dementia at follow-up with molecular imaging-based classification using C-11-dihydotetrabenazine PET measurement of striatal dopamine terminal integrity and C-11-Pittsburgh compound B (C-11-PiB) PET measurement of cerebral amyloid burden. Results: Eleven subjects were initially classified clinically as amnestic MCI, 7 as multidomain MCI, and 9 as nonamnestic MCI. At a mean follow-up of 3 y, 18 subjects converted to dementia. PET imaging evidence of significant cerebral amyloid deposition or nigrostriatal denervation was a strong predictor of conversion to dementia. There was only moderate concordance between expert clinical classifications and PET-based classifications of dementia subtypes. Conclusion: Combined PET molecular imaging of cerebral amyloid burden and striatal dopamine terminal integrity may be useful for identifying subjects at high risk for progression to dementia and in defining neurochemically differentiated subsets of MCI subjects.