Animal models in rheumatoid arthritis.
Animal models in rheumatoid arthritis.
复制标题
类风湿性关节炎的动物模型。
DOI：
10.1097/00002281-199505000-00008
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发表时间：
1995
影响因子：
5.1
通讯作者：
O'Sullivan,FX
中科院分区：
文献类型：
--
作者：
Houri,JM;O'Sullivan,FX
建立了两种新的类风湿关节炎模型。植入人滑膜组织的SCID（严重联合免疫缺陷）小鼠和人HLA-DR 4-CD 4转基因小鼠代表了在发病机制研究中使用动物模型的新的和重要的方法。对大鼠链球菌细胞壁关节炎的新研究表明，[β] 1整合素介导的细胞-基质相互作用参与炎症性滑膜炎的诱导和持续，全身给予白细胞介素-4可能通过影响单核细胞功能选择性抑制已建立的滑膜炎。一氧化氮作为滑膜炎症介质的重要性在类风湿性关节炎的促炎剂诱导模型中得到证实。在胶原蛋白诱导的关节炎模型中，有趣的新数据表明+/-T细胞参与了关节炎的发病机制，并且研究表明，紫杉醇药物具有抗炎作用。
Two new models for the study of rheumatoid arthritis have been established. SCID (severe combined immunodeficient) mice implanted with human synovial tissues and human HLA-DR4-CD4 transgenic mice represent novel and important approaches to the use of animal models in pathogenetic studies. New studies of streptococcal cell wall arthritis in rats demonstrated that [beta] 1 integrin-mediated cell-matrix interactions are involved in the induction and perpetuation of inflammatory synovitis and that systemic administration of interleukin-4 selectively suppresses established synovitis, presumably by effects on monocyte function. The importance of nitric oxide as a mediator of synovial inflammation was confirmed in the adjuvant-induced model of rheumatoid arthritis. In the collagen-induced arthritis model, interesting new data have implicated+/-T cells in the pathogenesis of arthritis, and the antineoplastic drug taxol was shown to have anti-inflammatory effects.