A case-control study of the risk factors associated with sinonasal inverted papilloma
A case-control study of the risk factors associated with sinonasal inverted papilloma
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DOI：
10.2500/ajra.2010.24.3408
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发表时间：
2010-01-01
影响因子：
2.6
通讯作者：
Tong, Michael C. F.
中科院分区：
文献类型：
--
作者：
Sham, Cheuk Lun;Lee, Dennis L. Y.;Tong, Michael C. F.
背景：鼻腔鼻窦内翻性乳头状瘤（IP）的病因不明。本研究的目的是评估可能的危险因素与IP方法：这是一个病例对照流行病学研究在三级转诊中心。50例IP患者和150名匹配的对照组使用疑似危险因素的问卷进行了访谈。对风险因素进行单变量分析，并计算匹配的比值比、相应的95% CI和p值。结果：户外和工业职业与IP的发生有关。吸烟、饮酒、变应性鼻炎、鼻窦炎、鼻息肉、非鼻窦乳头状瘤和非鼻窦恶性肿瘤史与IP的发生无显著性关系。结论：户外和工业职业与IP的发生相关，可能是IP的潜在危险因素。今后的研究有必要进一步评估个人的职业类型和所涉及的化学品。(Am J Rhinol Allergy 24，e37-e40，2010; doi：10.2500/ajra.2010.24.3408）
Background: The etiology of sinonasal inverted papilloma (IP) is unknown. This study was designed to evaluate the possible risk factors associated with IPMethods: This is a case-control epidemiology study in a tertiary referral center. Fifty patients with IP and 150 matched controls were interviewed using a questionnaire on suspected risk factors. Univariate analysis of the risk factors and calculation of the matched odds ratios, the corresponding 95% CIs, and p values was performed. Significant risk factors were further studied using conditional logistic regression analysis.Results: Outdoor and industrial occupations were associated with IP. Tobacco smoking, drinking alcohol, history of allergic rhinitis, sinusitis, nasal polyp, non-sinonasal papilloma and non-sinonasal malignancy were not significant factors.Conclusion: Outdoor and industrial occupations were associated with IP and may be potential risk factors. Future studies are warranted to further evaluate the individual type of occupation and chemical involved. (Am J Rhinol Allergy 24, e37-e40, 2010; doi: 10.2500/ajra.2010.24.3408)