Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide
Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide
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DOI：
10.1016/j.trci.2019.09.017
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发表时间：
2019-01-01
影响因子：
4.8
通讯作者：
Biessels, Geert Jan
中科院分区：
文献类型：
--
作者：
Gladman, Jordan T.;Corriveau, Roderick A.;Biessels, Geert Jan
血管对认知障碍和痴呆 (VCID) 的影响的研究旨在了解脑血管生物学在认知衰退中的重要性。 VCID 的预防和治疗将对痴呆症相关疾病负担产生重大影响，因此是痴呆症研究中一个重要的新兴目标。本文介绍了 VCID 联盟，该联盟专注于多学科方法来确定关键病理目标并开发诊断工具，其目标是弥合基础研究和临床试验之间的鸿沟。这些多机构、多学科联盟的成员对 VCID 的历史和新兴科学以及 VCID 联盟如何解决 VCID 中一些更复杂的问题并推动该领域向前发展提供了展望。这些联盟以及其他类似联盟特别适合解决将研究转化为临床的一些最困难的障碍。
The research into vascular contributions to cognitive impairment and dementia (VCID) aims to understand the importance of cerebrovascular biology in cognitive decline. Prevention and treatment of VCID is poised to have major impact on dementia-related disease burden and is thus a critical emerging objective in dementia research. This article presents VCID consortia focused on multidisciplinary approaches to identify key pathologic targets and develop diagnostic tools with the goal of bridging the divide between basic research and clinical trials. Members of these multi-institute, multidisciplinary consortia provide a prospective on the history and emerging science of VCID and how VCID consortia can address some of the more complex questions in VCID and drive the field forward. These consortia, and others like them, are uniquely suited to tackle some of the most difficult obstacles in translating research to the clinic.