Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease
Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease
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冠状动脉疾病患者不宁腿综合征的患病率和意义
DOI：
10.1016/j.amjcard.2019.02.017
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Daida Hiroyuki
中科院分区：
文献类型：
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作者：
Yatsu Shoichiro;Kasai Takatoshi;Suda Shoko;Matsumoto Hiroki;Ishiwata Sayaki;Shiroshita Nanako;Kato Mitsue;Kawana Fusae;Murata Azusa;Shimizu Megumi;Shitara Jun;Kato Takao;Hiki Masaru;Sai Eiryu;Miyauchi Katsumi;Daida Hiroyuki
不宁腿综合症(RLS)的特征是腿部不安和感觉障碍，主要在夜间和休息时，扰乱睡眠和生活质量。报告的RLS患病率为2%至5%。尽管RLS与冠状动脉疾病有关，但RLS在冠心病患者中的患病率和临床意义仍不清楚。我们招募了接受经皮冠状动脉介入治疗的冠心病患者。根据国际标准确定RLS患者。分别采用爱普沃斯嗜睡量表、匹兹堡睡眠质量指数和简表-8评估主观困倦、睡眠质量和与健康相关的生活质量。在326例冠心病患者中，26例(8.0%)有RLS。患有和不患有RLS的患者之间的特征没有显著差异。RLS患者的睡眠质量和生活质量受到更多的干扰(匹兹堡睡眠质量指数评分，7.4±2.4vs5.6±2.5，p<；0.001；躯体部分总分和精神部分总分分别为(89.6±1.8vs43.5±0.5，p = 0.042和45.2±8.4vs48.4±7.4p = 0.037)，而Epworth嗜睡量表得分(8.22±5.1vs7.1±4.8，p = 0.293)差异无统计学意义。在多元线性回归分析中，RLS与匹兹堡睡眠质量指数(β = 0.174，p<；0.001)、身体成分摘要(β=−0.127，p = 0.029)和心理成分摘要(β = −0.113，p = 0.042)得分独立相关。总而言之，在冠状动脉疾病患者中，RLS的患病率与普通人群中的报告相比相对较高。在冠心病患者中，RLS的存在与睡眠质量和健康相关的生活质量相关。
Restless legs syndrome (RLS), characterized by leg restlessness and dysesthesia predominantly at night and at rest, disrupts sleep and quality of life. The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clinical significance of RLS in coronary artery disease patients remain unknown. We enrolled coronary artery disease patients who underwent percutaneous coronary intervention. Patients with RLS were identified according to international criteria. Subjective sleepiness, sleep quality, and health-related quality of life were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Short Form-8, respectively. Among 326 patients with coronary artery disease, 26 (8.0%) had RLS. There were no significant differences in characteristics between patients with and without RLS. Sleep quality and quality of life were more disrupted in patients with RLS (Pittsburgh Sleep Quality Index score, 7.4 ± 2.4 vs 5.6 ± 2.5, p <0.001; physical component summary and mental component summary scores of Short Form-8, 39.6 ± 1.8 vs 43.5 ± 0.5, p = 0.042 and 45.2 ± 8.4 vs 48.4 ± 7.4, p = 0.037, respectively), despite no significant difference in Epworth Sleepiness Scale score (8.2 ± 5.1 vs 7.1 ± 4.8, p = 0.293). In multiple linear regression analyses, RLS was independently associated with Pittsburgh Sleep Quality Index (β = 0.174, p <0.001), physical component summary (β = −0.127, p = 0.029), and mental component summary (β = −0.113, p = 0.042) scores. In conclusion, in patients with coronary artery disease, the prevalence of RLS was relatively high compared to that reported in the general population. The presence of RLS was associated with disrupted sleep quality and health-related quality of life in coronary artery disease patients.