Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy
Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy
复制标题
海马体功能网络变化导致癫痫抑郁症状
DOI：
10.1016/j.seizure.2018.06.001
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发表时间：
2018-08
影响因子：
3
通讯作者：
Wang Xin
中科院分区：
文献类型：
--
作者：
Peng Weifeng;Mao Lingyan;Yin Dazhi;Sun Wei;Wang He;Zhang Qianqian;Wang Jing;Chen Caizhong;Zeng Mengsu;Ding Jing;Wang Xin
PurposeOur study aimed to investigate the functional connectivity（FC）between hippocampus and other brain regions in epilepsy patients with depression symptoms.MethodsEpilepsy patients with and without depression symptoms，assessed using the 17-item汉密尔顿抑郁量表scores，were enrolled.健康志愿者作为对照组。采用静息态功能磁共振成像（DPARSFA2.0）软件进行数据处理。结果癫痫患者小脑（尤其是左小脑半球）的ReHo值显著低于健康对照组，伴抑郁症状的癫痫患者（EP + DS组）的ReHo值显著低于无抑郁症状的癫痫患者（EP-DS组，p <0. 05）。此外，EP + DS组右侧海马与双侧小脑之间的FC显著大于EP-DS组（p < 0.05）。此外，在EP + DS组中，双侧额叶，包括右侧前扣带回皮质的ReHo值异常，以及右侧海马与双侧额叶之间的FC变化。轻微的变化，在FC之间的颞叶和顶叶也被发现在epilepsy patients.ConclusionThe功能性右大脑半球小脑回路可能有助于癫痫抑郁症状的发病机制，与情绪相关的大脑区域，如额叶和颞叶除外。调节海马-小脑回路是治疗癫痫伴抑郁症状的潜在策略。
PurposeOur study aimed to investigate the functional connectivity (FC) between the hippocampus and other brain regions in epilepsy patients with depressive symptoms.MethodsEpilepsy patients with and without depressive symptoms, assessed using the 17-item Hamilton Depression Rating Scale scores, were enrolled. Healthy volunteers were recruited as the control group. Resting state functional magnetic resonance imaging was performed, and the data were processed using Resting-State fMRI (DPARSFA2.0) software. The regional homogeneity (ReHo) values and the FC between the right hippocampus and other brain regions were analysed.ResultsThe ReHo value of the cerebellum (particularly the left cerebellar hemisphere) was significantly lower in epilepsy patients than in healthy controls, and was lower in epilepsy patients with depressive symptoms (EP + DS group) than in those without depressive symptoms (EP-DS group, p < 0.05). Additionally, the FC between the right hippocampus and the bilateral cerebellum was significantly greater in the EP + DS group than in the EP-DS group (p < 0.05). Moreover, abnormal ReHo values in the bilateral frontal lobes, including the right anterior cingulate cortex, and changes in the FC between the right hippocampus and the bilateral frontal lobes were found in the EP + DS group. Minor changes in the FC between the temporal and parietal lobes were also found in the epilepsy patients.ConclusionThe functional right hippocampus–cerebellum circuit might contribute to the pathogenesis of depressive symptoms in epilepsy, with the exception of brain areas associated with emotion such as the frontal and temporal lobes. Modulating the hippocampus–cerebellum circuit is a potential therapeutic strategy for epilepsy patients with depressive symptoms.
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DOI：
--
发表时间：
1994-06
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
H. Mayberg;P. Lewis;W. Regenold;H. Wagner
通讯作者：
H. Mayberg;P. Lewis;W. Regenold;H. Wagner
影响因子：
2.6
作者：
Weifeng Peng;Jing Ding;Lingyan Mao;Xin Li;Liang Liang-Liang;Caizhong Chen;Wei-zhong Cheng;Wei Fan;Xin Wang
通讯作者：
Weifeng Peng;Jing Ding;Lingyan Mao;Xin Li;Liang Liang-Liang;Caizhong Chen;Wei-zhong Cheng;Wei Fan;Xin Wang
使用全脑功能连接识别重度抑郁症：多变量模式分析
影响因子：
14.5
作者：
Zeng, Ling-Li;Shen, Hui;Hu, Dewen
通讯作者：
Hu, Dewen
影响因子：
6.6
作者：
Zimmerman, Mark;Martinez, Jennifer H.;Dalrymple, Kristy
通讯作者：
Dalrymple, Kristy
影响因子：
14.5
作者：
Schmahmann, JD;Sherman, JC
通讯作者：
Sherman, JC