Copper and ischemic heart disease
Copper and ischemic heart disease
复制标题
铜与缺血性心脏病
DOI：
10.1007/bf02987211
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发表时间：
1983
影响因子：
3.9
通讯作者：
L. Klevay
中科院分区：
文献类型：
--
作者：
L. Klevay
铜的绝对或相对缺乏被假设为缺血性心脏病的病因学中最重要的。根据最近的估计，在美国，只有25%的饮食含有成人每天所需的2毫克铜。这些饮食中的一些具有锌与铜的比率大于那些在动物中产生高血脂症的饮食。锌与铜的比例与饮食特征、器官分析、临床状态和环境特征之间存在许多流行病学关联，这些特征将这些元素的代谢与缺血性心脏病的解剖学、化学、病理学、药理学和生理学联系起来。动物缺乏铜或暴露于高饮食锌铜比，这可能会产生相对铜缺乏症，是高血脂症和高尿酸血症，并有葡萄糖耐受不良和心电图异常。他们的心脏和动脉有异常的结缔组织，脂质沉积和炎症变化;他们突然死亡，通常伴有心脏破裂。在铜缺乏的男性和门克斯病（无法吸收铜）的儿童中发现了高脂血症和葡萄糖耐受不良。
Absolute or relative deficiency of copper is hypothesized to be of prime importance in the etiology of ischemic heart disease. According to recent estimates, only 25% of the diets in the United States contain the 2 mg of copper thought to be required daily by adults. Some of these diets have ratios of zinc to copper greater than those that have produced hypercholesteremia in animals. There are many epidemiologic associations between the ratio of zinc to copper and dietary characteristics, organ analyses, clinical status, and environmental features that relate the metabolism of these elements to the anatomy, chemistry, pathology, pharmacology, and physiology of ischemic heart disease. Animals deficient in copper or exposed to a high dietary ratio of zinc to copper, which can produce a relative copper deficiency, are hypercholesteremic and hyperuricemic, and have glucose intolerance and abnormalities of the electrocardiogram. Their hearts and arteries have abnormal connective tissue, lipid deposits, and inflammatory changes; they die suddenly, often with ruptured hearts. Hypercholesteremia and glucose intolerance have been found in men depleted of copper and in children with Menkes’ disease, an inability to absorb copper.