Dynamically controlled protein tunneling paths in photosynthetic reaction centers
Dynamically controlled protein tunneling paths in photosynthetic reaction centers
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DOI：
10.1126/science.290.5489.114
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发表时间：
2000-10-06
期刊：
影响因子：
56.9
通讯作者：
Onuchic, JN
中科院分区：
文献类型：
--
作者：
Balabin, IA;Onuchic, JN
Marcus理论解释了热核运动如何调节蛋白质电子转移反应中供体和受体位点之间的能隙，然而，热核运动也可能调节这些反应之间的电子隧穿。在这里，我们确定了一种新的核动力学放大机制，当主要隧道通道管之间的干扰是破坏性的时，它起着核心作用。在这些情况下，隧道作用发生在远离平衡的蛋白质构象中，使破坏性干扰最小化。作为一个例子，我们展示了这种动态放大机制如何影响光合反应中心的某些反应速率，因此可能对生物功能至关重要。
Marcus theory has explained how thermal nuclear motions modulate the energy gap between donor and acceptor sites in protein electron transfer reactions, Thermal motions, however, may also modulate electron tunneling between these reactions. Here we identify a new mechanism of nuclear dynamics amplification that plays a central role when interference among the dominant tunneling pathway tubes is destructive. In these cases, tunneling takes place in protein conformations far from equilibrium that minimize destructive interference. As an example, we demonstrate how this dynamical amplification mechanism affects certain reaction rates in the photosynthetic reaction center and therefore may be critical for biological function.