NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation.
NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation.
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DOI：
10.1098/rstb.2013.0131
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发表时间：
2014-01-05
期刊：
影响因子：
--
通讯作者：
Collingridge GL
中科院分区：
文献类型：
--
作者：
Park P;Volianskis A;Sanderson TM;Bortolotto ZA;Jane DE;Zhuo M;Kaang BK;Collingridge GL
N-甲基-d-天冬氨酸受体（NMDAR）依赖性长时程增强（LTP）被广泛研究，因为它被认为使用许多形式的学习和记忆所需的相同分子机制。不幸的是，存在许多争议，尤其是关于LTP表达位点的看似简单的问题。在这里，我们回顾了我们最近的工作和一些关于这一主题的广泛文献，并提出了新的数据，共同表明，LTP可以解释，在其最初的几个小时内，由至少三个机制不同的过程，都是由NMDARs的突触激活触发的共存。
N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) is extensively studied since it is believed to use the same molecular mechanisms that are required for many forms of learning and memory. Unfortunately, many controversies exist, not least the seemingly simple issue concerning the locus of expression of LTP. Here, we review our recent work and some of the extensive literature on this topic and present new data that collectively suggest that LTP can be explained, during its first few hours, by the coexistence of at least three mechanistically distinct processes that are all triggered by the synaptic activation of NMDARs.
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影响因子：
3.4
作者：
Bortolotto, ZA;Collingridge, GL
通讯作者：
Collingridge, GL
影响因子：
2.9
作者：
Abbas, Abdul-Karim;Dozmorov, Mikhail;Wigstrom, Holger
通讯作者：
Wigstrom, Holger
影响因子：
5.5
作者：
CLARK, KA;COLLINGRIDGE, GL
通讯作者：
COLLINGRIDGE, GL
影响因子：
64.8
作者：
DOLPHIN, AC;ERRINGTON, ML;BLISS, TVP
通讯作者：
BLISS, TVP
影响因子：
5.3
作者：
Bayazitov, Ildar T.;Richardson, Robert J.;Zakharenko, Stanislav S.
通讯作者：
Zakharenko, Stanislav S.