High signal intensity on magnetic resonance imaging is a better predictor of neurobehavioral performances than blood manganese in asymptomatic welders
High signal intensity on magnetic resonance imaging is a better predictor of neurobehavioral performances than blood manganese in asymptomatic welders
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DOI：
10.1016/j.neuro.2009.04.002
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发表时间：
2009-07-01
期刊：
影响因子：
3.4
通讯作者：
Jeong, Kyoung Sook
中科院分区：
文献类型：
--
作者：
Chang, Yongmin;Kim, Yangho;Jeong, Kyoung Sook
目的：本研究的目的是评估亚临床神经系统的影响焊工，使用广泛的列表神经行为电池，并确定是否有苍白球指数（PI）和亚临床神经行为效应之间的联系，在频谱锰（Mn）神经病学。方法：共有43名无症状男性焊工和29名年龄和性别匹配的健康对照者完成了问卷调查，并接受血液检查、脑部磁共振成像（MRI）扫描和广泛的神经行为检查。结果：数字符号听觉语言学习测验（延迟回忆）、复杂图形测试（复制和立即回忆），数字广度，语言流畅性测试，Stroop测试，凹槽钉板，手指敲击，震颤的频率离散度和谐波指数以及手协调的最大频率在焊工和对照个体之间显示出差异。两组在简单反应时间、姿势摇摆、嗅觉测试和情绪状态（POMS）方面没有差异。血锰水平被证明与凹槽钉板（优势手）和复杂图形测试（复制）结果显着相关。PI与数字符号，数字跨度落后，Stroop字和Stroop错误指数，和槽钉板（优势手）results.Conclusions：目前的研究结果，有几个神经行为缺陷和PI之间的显着相关性，以及血锰表明，他们可能是由于锰暴露在焊接烟雾。本研究还表明，PI是一个更好的预测神经行为的性能比血锰水平在无症状焊工。(C)2009 Elsevier Inc. All rights reserved.
Objectives: The aim of the study was to evaluate subclinical neurological effects in welders, using an extensive list of neurobehavioral batteries and determine if there is a link between pallidal index (PI) and subclinical neurobehavioral effects in the spectrum of manganese (Mn) symptomatology.Methods: A total of 43 asymptomatic male welders and 29 age- and sex-matched healthy control individuals completed questionnaires, and underwent blood examinations, brain magnetic resonance imaging (MRI) scans, and a wide range of neurobehavioral examinations.Results: Digit symbol, auditory verbal learning test (delayed recall), complex figure test (copy and immediate recall), digit span, verbal fluency test, Stroop test, grooved pegboard, finger tapping, frequency dispersion and harmonic index of tremor, and maximum frequency of hand coordination showed differences between welders and control individuals. No differences were noted for simple reaction time, postural sway, smell test, and profile of mood states (POMS). Blood Mn levels were shown to be significantly associated with grooved pegboard (dominant hand) and complex figure test (copy) results. PI was significantly associated with digit symbol, digit span backward, Stroop Word and Stroop error index, and grooved pegboard (dominant hand) results.Conclusions: The present findings that there were significant correlations between several neurobehavioral deficits and PI as well as blood Mn suggest that they may be attributed to Mn exposure in welding fumes. The present study also shows that PI is a better predictor of neurobehavioral performance than blood Mn levels in asymptomatic welders. (C) 2009 Elsevier Inc. All rights reserved.