Characteristics of dynamic processing in the visual field of patients with age-related maculopathy
Characteristics of dynamic processing in the visual field of patients with age-related maculopathy
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DOI：
10.1007/s00417-007-0641-2
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发表时间：
2008-01-01
影响因子：
2.7
通讯作者：
Strasburger, Hans
中科院分区：
文献类型：
--
作者：
Eisenbarth, Werner;MacKeben, Manfred;Strasburger, Hans
目的通过测量运动灵敏度、双脉冲分辨率和临界闪烁融合，探讨老年性黄斑病变（ARM）患者的视野动态加工特征。方法14例ARM患者（18眼）、14例年龄匹配的对照组（19眼）和7例青年对照组（8眼）作为研究对象。运动对比阈值由四个选项强制选择（4 afc）楼梯程序确定，Kernbach对其进行了修改，以呈现在四个方向之一的静止时空高斯包络内移动的格纹（尺寸=3.8度）。在水平子午线上进行10度、20度、30度、40度和60度的测量。DPR被定义为受试者使用9倍交错自适应程序检测到的最小时间间隙，刺激位于主经络和斜经络上偏心5度、10度和20度的同心圆上。临界闪烁融合阈值（Critical flicker fusion threshold， CFF）和Lanthony D-15色觉测试是在中央窝进行的，受试者可以自由地使用他们的中央窝或任何他们需要使用的视网膜区域，因为他们的视网膜病变是由ARM引起的。所有测量均在光敏条件下进行。结果ARM患者的运动对比敏感度明显降低（0.23-0.66 log单位，p < 0.01），不仅在黄斑，而且在偏心度为20度的区域。在两个对照组中，运动对比敏感度随视网膜偏心率（0.009-0.032对数单位/度）和年龄（0.01对数单位/年）而系统性下降。健康受试者的双脉冲阈值在中心视野范围内大致恒定，在10度半径外增加（1.73 ms/度）。与年龄匹配的对照组相比，偏心度为20度的ARM受试者的DPR阈值升高（23-32 ms, p < 0.01），其中央凹cff升高5.5 Hz或14% （p < 0.01）。结论ARM患者的中央视野明显超出黄斑边界，偏心度达20度，动态处理特性严重受损。
Purpose To investigate the characteristics of dynamic processing in the visual field of patients with age-related maculopathy (ARM) by measuring motion sensitivity, double-pulse resolution (DPR), and critical flicker fusion.Methods Fourteen subjects with ARM (18 eyes), 14 age-matched controls (19 eyes), and 7 young controls (8 eyes) served as subjects. Motion contrast thresholds were determined by a four-alternative forced-choice (4 afc) staircase procedure with a modification by Kernbach for presenting a plaid (size=3.8 degrees) moving within a stationary spatial and temporal Gaussian envelope in one of four directions. Measurements were performed on the horizontal meridian at 10 degrees, 20 degrees, 30 degrees, 40 degrees, and 60 degrees eccentricity. DPR was defined as the minimal temporal gap detectable by the subject using a 9-fold interleaved adaptive procedure, with stimuli positioned on concentric rings at 5 degrees, 10 degrees, and 20 degrees eccentricity on the principal and oblique meridians. Critical flicker fusion thresholds (CFF) and the Lanthony D-15 color vision test were applied foveally, and the subjects were free to use their fovea or whatever retinal area they needed to use instead, due to their retinal lesions caused by ARM. All measurements were performed under photopic conditions.Results Motion contrast sensitivity in subjects with ARM was pronouncedly reduced (0.23-0.66 log units, p < 0.01), not only in the macula but in a region up to 20 degrees eccentricity. In the two control groups, motion contrast sensitivity systematically declined with retinal eccentricity (0.009-0.032 log units/degree) and with age (0.01 log units/year). Double-pulse thresholds in healthy subjects were approximately constant in the central visual field and increased outside a radius of 10 degrees (1.73 ms/degree). DPR thresholds were elevated in subjects with ARM (by 23-32 ms, p < 0.01) up to 20 degrees eccentricity, and their foveal CFFs were increased by 5.5 Hz or 14% (p < 0.01) as compared with age-matched controls.Conclusions Dynamic processing properties in subjects with ARM are severely impaired in the central visual field up to 20 degrees eccentricity, which is clearly beyond the borders of the macula.