MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521
MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521
复制标题
MiR-9通过靶向锌指蛋白521促进小鼠骨髓间充质干细胞的神经分化
DOI：
10.1016/j.neulet.2012.03.032
复制
发表时间：
2012-05-02
影响因子：
2.5
通讯作者：
Jia, Yanjie
中科院分区：
文献类型：
--
作者：
Han, Rui;Kan, Quancheng;Jia, Yanjie
MicroRNAs （miRNAs）是一类非编码RNA，其功能是作为RNA干扰途径的内源性触发器。最近的研究表明，microRNA-9 （miR-9）在干细胞和神经前体细胞的发育和分化中起调节作用。我们发现miR-9能够促进骨髓间充质干细胞（MSCs）的分化，但miR-9在这一过程中的机制尚不清楚。越来越多的研究发现，锌指蛋白521 （Zfp521）在大多数未成熟细胞中表达高，并随着分化而降低。Zfp521能诱导胚胎干细胞神经转化。然而，关于Zfp521的表达及其与miR-9在MSCs神经分化中的关系，我们知之甚少。在本研究中，我们发现Zfp521的表达随着MSCs的神经分化而下降，miR-9可以通过靶向Zfp521促进神经分化。2012爱思唯尔爱尔兰有限公司版权所有。
MicroRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Recent studies have shown that microRNA-9 (miR-9) plays a regulatory role in the development and differentiation of stem cells and neural precursor cells. We have found that miR-9 is able to promote the differentiation of bone marrow mesenchymal stem cells (MSCs), but the mechanisms of miR-9 in this process remains poorly understood. An increasing number of studies have found that zinc-finger protein 521 (Zfp521) expression is high in most immature cells and decreases with differentiation. Zfp521 could induce neural conversion of embryonic stem cells. However, little is known about the expression of Zfp521 and its relationship with miR-9 with respect to the neural differentiation of MSCs. In this study, we found the expression of Zfp521 declined with the neural differentiation of MSCs, and miR-9 could promote the neural differentiation via targeting Zfp521. (C) 2012 Elsevier Ireland Ltd. All rights reserved.