Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET
Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET
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DOI：
10.1016/j.nucmedbio.2003.07.004
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发表时间：
2004-02-01
影响因子：
3.1
通讯作者：
Iwata, R
中科院分区：
文献类型：
--
作者：
Ishiwata, K;Kawamura, K;Iwata, R
我们研究了O-[C-11]甲基-L-酪氨酸和O-[F-18]氟甲基-L-酪氨酸作为正电子发射示踪剂用于肿瘤成像的潜力。这两种示踪剂在AH 109 A肝癌大鼠中具有相似的分布模式，胰腺和AH 109 A在较小程度上显示出最高的摄取。AH 109 A中两种示踪剂的摄取和AH 109 A与组织的摄取比（AH 109 A与骨的摄取比除外）在60 min内逐渐增加。O-[C-11]甲基-L-酪氨酸代谢稳定，而O-[F-18]氟甲基-L-酪氨酸的代谢物含量可忽略不计。两种示踪剂都显示出肿瘤成像的潜力。(C)2004年爱思唯尔公司All rights reserved.
We investigated the potential of O-[C-11]methyl-L-tyrosine and O-[F-18]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[C-11]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[F-18]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging. (C) 2004 Elsevier Inc. All rights reserved.