The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma.
The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma.
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DOI：
10.3389/fonc.2021.649107
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发表时间：
2021
影响因子：
4.7
通讯作者：
Taheri M
中科院分区：
文献类型：
--
作者：
Ghafouri-Fard S;Gholipour M;Hussen BM;Taheri M
肝细胞癌是最致命的人类恶性肿瘤之一。这种类型的癌症与几种环境、病毒和生活方式风险因素有关。长链非编码rna （lncRNAs）的失调是导致HCC发病的表观遗传因素之一。这些转录物调节几种肿瘤抑制基因和癌基因的表达，并改变癌症相关信号轴的活性。一些lncrna如NEAT1、MALAT1、ANRIL和SNHG1在HCC样本中上调。另一方面，一些所谓的肿瘤抑制lncrna，即CASS2和MEG3在HCC中下调。lncrna和mirna之间的相互作用调节了一些参与HCC发病机制的mRNA编码基因的表达。H19/miR-15b/CDC42、H19/miR-326/TWIST1、NEAT1/miR-485/STAT3、MALAT1/miR-124-3p/Slug、MALAT1/miR-195/EGFR、MALAT1/miR-22/SNAI1和ANRIL/miR-144/PBX3轴是HCC病理生物学中的功能轴。在某些人群中，基因组非编码区域内的一些遗传多态性与HCC的风险有关。在本文中，我们描述了lncrna在HCC中影响的最新发现。
Hepatocellular carcinoma (HCC) is among the utmost deadly human malignancies. This type of cancer has been associated with several environmental, viral, and lifestyle risk factors. Among the epigenetic factors which contribute in the pathogenesis of HCC is dysregulation of long non-coding RNAs (lncRNAs). These transcripts modulate expression of several tumor suppressor genes and oncogenes and alter the activity of cancer-related signaling axes. Several lncRNAs such as NEAT1, MALAT1, ANRIL, and SNHG1 have been up-regulated in HCC samples. On the other hand, a number of so-called tumor suppressor lncRNAs namely CASS2 and MEG3 are down-regulated in HCC. The interaction between lncRNAs and miRNAs regulate expression of a number of mRNA coding genes which are involved in the pathogenesis of HCC. H19/miR-15b/CDC42, H19/miR-326/TWIST1, NEAT1/miR-485/STAT3, MALAT1/miR-124-3p/Slug, MALAT1/miR-195/EGFR, MALAT1/miR-22/SNAI1, and ANRIL/miR-144/PBX3 axes are among functional axes in the pathobiology of HCC. Some genetic polymorphisms within non-coding regions of the genome have been associated with risk of HCC in certain populations. In the current paper, we describe the recent finding about the impact of lncRNAs in HCC.