Outcome of dialysis in children with human immunodeficiency virus infection.
Outcome of dialysis in children with human immunodeficiency virus infection.
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人类免疫缺陷病毒感染儿童的透析结果。
DOI：
10.1007/s00467-008-0976-x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Woroniecki,RobertP
中科院分区：
文献类型：
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作者：
Gordillo,Roberto;Kumar,Juhi;DelRio,Marcela;Flynn,JosephT;Woroniecki,RobertP
人类免疫缺陷病毒（HIV）感染在患有终末期肾病（ESKD）的儿童中所占比例不详。我们的目的是比较肾脏替代治疗（RRT）在HIV和其他诊断的ESKD患者中的结果，并检查HIV引起的ESKD的患病率。我们分析了2002年2月至2007年2月在本中心随访的12例HIV透析患者和32例非HIV透析患者的Kt/V、发病率、死亡率、超声心动图、营养和移植状况。HIV患者的身体质量指数（BMI）低于非HIV患者，Kt/V高于非HIV患者。HIV患者的缩短率明显降低。在研究期间，艾滋病毒组有6人死亡，非艾滋病毒组有1人死亡。血液透析（HD）是城市环境中艾滋病毒感染者普遍采用的RRT模式，以Kt/V衡量，艾滋病毒患者的充分性高于非艾滋病毒患者。体重指数下降和心血管疾病可能与接受RRT治疗的艾滋病毒儿童死亡率增加有关。
Human immunodeficiency virus (HIV) infection accounts for an unknown percentage of children with end-stage kidney disease (ESKD). Our objective was to compare the outcome of renal replacement therapy (RRT) in subjects with ESKD due to HIV and other diagnoses and to examine the prevalence of ESKD due to HIV. We analyzed Kt/V, morbidity, mortality, echocardiography, nutritional, and transplant status in 12 dialysis patients with HIV and 32 without HIV followed at our center between February 2002 and February 2007. Body mass index (BMI) was lower and Kt/V higher in HIV than in non-HIV patients. Shortening fraction was significantly lower in HIV patients. There were six deaths in the HIV group and one in the non-HIV group over the study period. Hemodialysis (HD) is the prevalent mode of RRT in HIV in urban settings, and its adequacy as measured by Kt/V was higher in HIV patients than in non-HIV patients. Decreased BMI and cardiovascular disease may be associated with increased mortality in children with HIV on RRT.