Cutaneous allodynia during cluster headache attacks.
Cutaneous allodynia during cluster headache attacks.
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DOI：
10.1111/j.1468-2982.2008.01794.x
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发表时间：
2009-07-01
期刊：
影响因子：
--
通讯作者：
Wober, C
中科院分区：
文献类型：
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作者：
Riederer, F;Selekler, H M;Wober, C
皮肤异常性疼痛发生在> 60%的发作性偏头痛患者中，或者仅发生在同侧头部的牵涉疼痛区域内，或者发生在同侧头部内外（1，2）。Burstein埃塔尔(3)已经描述了一个患者，在偏头痛发作后1小时，机械性和冷性异常性疼痛开始在同侧头部发展，2小时后异常性疼痛扩散到对侧头部和同侧前臂。作者假设，同侧头部的异常性疼痛反映了三叉神经尾侧核中二级神经元的敏化，而该区域以外的异常性疼痛与丘脑中三级神经元的敏化有关（3）。在丛集性头痛（CH）中，数据仅限于两项研究，一项研究显示10例患者中有4例出现皮肤异常性疼痛，另一项研究报告16例患者无异常性疼痛（4，5）。
Cutaneous allodynia occurs in> 60% of patients with episodic migraine, either solely within the referred pain area on the ipsilateral head or within and outside the ipsilateral head (1, 2). Burstein etal.(3) have described a patient in whom, 1h after migraine pain onset, mechanical and cold allodynia started to develop in the ipsilateral head and after 2 h allodynia spread to the contralateral head and the ipsilateral forearm. The authors hypothesized that allodynia on the ipsilateral head reflects sensitization of second-order neurons in trigeminal nucleus caudalis, and allodynia outside this area is related to sensitization of third-order neurons in the thalamus (3). In cluster headache (CH), data are limited to two studies, one showing cutaneous allodynia in four of 10 patients, and the other study reporting absence of allodynia in 16 patients (4, 5).