Synthesis of mesoporous silica nanoparticles by sol-gel as nanocontainer for future delivery applications
Synthesis of mesoporous silica nanoparticles by sol-gel as nanocontainer for future delivery applications
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DOI：
10.1016/j.bsecv.2017.03.002
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发表时间：
2017-05-01
影响因子：
3.4
通讯作者：
CastroInstituto, Yolanda
中科院分区：
文献类型：
--
作者：
Vazquez, Naiara I.;Gonzalez, Zoilo;CastroInstituto, Yolanda
在过去的十年中，介孔二氧化硅纳米颗粒作为药物输送系统的载体的发展呈指数增长。以正硅酸四乙酯（TEOS）为前驱体，十六烷基三甲基溴化铵（CTAB）为生孔剂，采用溶胶-凝胶法制备了二氧化硅载体。通过改变水/正硅酸盐的摩尔比、NH3/正硅酸盐的摩尔比和CTAB的用量，对合成条件进行了改进。采用扫描电镜（FESEM）、高分辨率透射电镜（HR-TEM）、N-2吸附-解吸等温线、zeta电位和动态光散射（DLS）对二氧化硅颗粒进行了表征。结果表明，CTAB的加入和H2O的加入对二氧化硅颗粒的比表面积和孔隙率有较大的影响。尽管二氧化硅介孔颗粒具有较高的表面反应性，但其分散性和稳定性都得到了保证。合成配方对颗粒形貌有较大影响，当水的摩尔比增大时，颗粒形貌由球形变为棒状。最大比表面积为1480m(2)/g，孔径范围为2.5 ~ 2.8 nm。(c) 2017 SECV。Elsevier Espana， S.L.U.出版
Development of mesoporous silica nanoparticles as carriers for drug delivery systems has increased exponentially during the last decade. The present work is focused on the synthesis of silica carriers by sol-gel from tetraethyl orthosilicate (TEOS) as precursor of silica and cetyltrimethylammonium bromide ( CTAB) as pore generating agent. The synthesis conditions were modified varying the molar ratio of water/TEOS, NH3/TEOS and amount of CTAB. The silica particles were characterized by scan electron microscopy techniques (FESEM), high resolution transmission electron microscopy (HR-TEM), N-2 adsorption-desorption isotherms, Zeta-potential and Dynamic Light Scattering (DLS). The results show that the specific surface area and the porosity of silica particles were strongly affected by the addition of CTAB and the amount of H2O. The dispersion and stability of silica mesoporous particlesis achieved in spite of the high surface reactivity. The synthesis formulation affects considerably to the particle morphology, which changes from spheres to rods when the molar ratio of H2O increases. A maximum specific surface area of 1480m(2)/g was obtained with pore sizes ranging 2.5-2.8 nm. (c) 2017 SECV. Published by Elsevier Espana, S.L.U.