Genetic basis of human breast cancer metastasis
Genetic basis of human breast cancer metastasis
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DOI：
10.1023/a:1014739131690
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发表时间：
2001-10-01
影响因子：
2.5
通讯作者：
Welch, DR
中科院分区：
文献类型：
--
作者：
Debies, MT;Welch, DR
一旦癌细胞扩散并形成继发性肿块，即使使用最先进的药物，乳腺癌在很大程度上也无法治愈。为了提高诊断和治疗水平，需要更好的标志物来区分临床相关的高概率细胞。宏观转移。在这篇综述中。我们总结了几个调控乳腺癌转移的基因。两类基因分别为转移激活因子（ras、MEK1、mta1、蛋白酶、粘附分子、趋化剂/受体、autotaxin、PKC、S100A4、RhoC、骨桥蛋白）和转移抑制因子（Nm23、E-cadherin、TIMPs、KiSS1、Kai1、Maspin、MKK4、BRMS1）。虽然大多数这些基因的作用机制尚未完全阐明，但一些线索正在出现并被提出。
Once cancer cells have spread and formed secondary masses, breast cancers are largely incurable even with state-of-the-art medicine. To improve diagnosis and therapy, better markers are needed to distinguish cells which have a high probability for causing clinically relevant. macroscopic metastasis. In this review. we summarize the several genes that regulate breast cancer metastasis. Two categories of genes are presented-metastasis activator (ras, MEK1, mta1, proteinases, adhesion molecules, chemoattractants/receptors, autotaxin, PKC, S100A4, RhoC, osteopontin) and metastasis suppressor (Nm23, E-cadherin, TIMPs, KiSS1, Kai1, Maspin, MKK4, BRMS1). While the mechanisms of action for most of these genes are not fully elucidated, some clues are emerging and are presented.