RENAL ELECTROLYTE CIRCADIAN-RHYTHMS - INDEPENDENCE FROM FEEDING AND ACTIVITY PATTERNS
RENAL ELECTROLYTE CIRCADIAN-RHYTHMS - INDEPENDENCE FROM FEEDING AND ACTIVITY PATTERNS
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DOI：
10.1152/ajprenal.1977.232.2.f128
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发表时间：
1977-01-01
影响因子：
--
通讯作者：
HERD, JA
中科院分区：
文献类型：
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作者：
MOOREEDE, MC;HERD, JA
本文研究了6只清醒的椅习松鼠猴（Saimiri sciureus）在12：12 h光暗（LD）周期的温控隔离室内的尿电解质昼夜节律与摄食、饮水和活动节律之间的相互关系。在0800 - 2000 h开灯（600 lx）和2000 - 0800 h关灯（小于1 lx）的情况下，自由采食猴的肾钾排泄量在0500 h降至每日最低值64 +/- 6 mueq/h，在1700 h升至最高值274 +/- 13 mueq/h。钠排泄在1000 h降至最低值13 +/- 2 mueq/h，在2100 h升至最高值43 +/- 6 mueq/h，而水排泄在0500 h降至最低值869 +/- 63穆尔/h，在1700 h升至最高值2，307 +/- 222穆尔/h。进食、饮水和活动仅发生在开灯期间。通过a）剥夺猴子的食物，B）剥夺猴子的水，和c）训练猴子在白天和晚上进行2小时的进食、饮水和活动，建立了排尿节律与进食、饮水和活动的昼夜变化的独立性。这三种治疗方案均未导致尿电解质或水排泄的昼夜节律的幅度或相位发生重大降低。这些发现表明，尿钾、钠和水排泄的昼夜节律是由并非被动依赖于进食、饮水和活动的行为模式的机制控制的。
The interrelationships between urinary electrolyte circadian rhythms and rhythms of feeding, drinking and activity were studied in six conscious chair-acclimatized squirrel monkeys (Saimiri sciureus) kept in temperature-controlled isolation chambers on a light-dark (LD) 12:12 h cycle. With lights on (600 lx) from 0800 to 2000 h and off (less than 1 lx) from 2000 to 0800 h, renal potassium excretion in monkeys fed ad libitum fell to a daily minimum of 64 +/- 6 mueq/h at 0500 h and rose to a maximum of 274 +/- 13 mueq/h at 1700 h. Sodium excretion fell to a minimum of 13 +/- 2 mueq/h at 1000 h and rose to a maximum of 43 +/- 6 mueq/h at 2100 h, while water excretion fell to a minimum of 869 +/- 63 mul/h at 0500 h and rose to a maximum of 2,307 +/- 222 mul/h at 1700 h. Feeding, drinking, and activity occurred only during the lights-on period. Independence of the urinary rhythms from diurnal variations in feeding, drinking, and activity was established a) by depriving monkeys of food, b) by depriving monkeys of water, and c) by training monkeys to perform a 2-hourly schedule of feeding, drinking, and activity throughout day and night. None of these three regimens resulted in major reductions of the amplitude, or changes in the phase of the circadian rhythms of urinary electrolyte or water excretion. These findings indicate that the circadian rhythms of urinary potassium, sodium, and water excretion are controlled by mechanisms that are not passively dependent on the behavioral patterns of feeding, drinking, and activity.