Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates
Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates
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DOI：
10.1128/aac.01637-09
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发表时间：
2010-04-01
影响因子：
4.9
通讯作者：
Seifert, Harald
中科院分区：
文献类型：
--
作者：
Higgins, Paul G.;Stubbings, Will;Seifert, Harald
本研究比较了非那氟沙星（一种在酸性pH下显示增强活性的新型氟喹诺酮）和环丙沙星在标准条件（pH 7.2）和pH 5.8下对鲍曼不动杆菌的活性。总体而言，在酸性条件下，非那氟沙星表现出比环丙沙星更优越的上级活性。此外，在pH 7.2下，非那氟沙星显示出与环丙沙星相当的活性。因此，非那氟沙星可能是一种很有前途的治疗A.鲍曼不动杆菌感染在酸性身体隔间。
This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH, and that of ciprofloxacin against Acinetobacter baumannii under standard conditions (pH 7.2) and at a pH of 5.8. Overall, finafloxacin demonstrated superior activity to ciprofloxacin under acidic conditions. Furthermore, finafloxacin showed comparable activity to ciprofloxacin at pH 7.2. Hence, finafloxacin could be a promising new antimicrobial agent for the treatment of A. baumannii infections at acidic body compartments.