Subject-Specific Finite Element Modeling of the Tibiofemoral Joint Based on CT, Magnetic Resonance Imaging and Dynamic Stereo-Radiography Data in Vivo
Subject-Specific Finite Element Modeling of the Tibiofemoral Joint Based on CT, Magnetic Resonance Imaging and Dynamic Stereo-Radiography Data in Vivo
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DOI：
10.1115/1.4026228
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发表时间：
2014-04-01
影响因子：
1.7
通讯作者：
Zhang, Xudong
中科院分区：
文献类型：
--
作者：
Carey, Robert E.;Zheng, Liying;Zhang, Xudong
在本文中，我们提出了一种新的方法，根据在体内计算机断层扫描（CT），磁共振成像（MRI）和动态立体摄影（DSX）数据的胫股关节的特定主题的有限元建模。我们实施并比较了两种技术，将体内骨骼运动学作为边界条件：一种是在非负重仰卧位使用MRI测量的胫股运动学，并允许五个自由度（不包括屈曲-伸展）;另一个使用DSX测量的胫股运动学，轴承站立位置，并且仅允许响应于相同的力的轴向平移。模型预测的验证和比较采用了来自半月板移植研究受试者的数据，该受试者具有切除的半月板和完整的膝关节。模型预测的软骨-软骨接触面积进行了检查，从一个新的原位接触面积分析（ISCAA），其中未变形的股骨和胫骨软骨之间的交叉体积的特点，以确定接触的“基准”。结果表明，基于DSX的模型预测的接触面积与基准非常接近，并且优于基于MRI的模型：前者预测的接触质心平均接近基准位置85%。基于DSX的FE模型预测还表明，（外侧）椎间盘切除术增加了外侧间室的接触面积，并增加了两个间室的最大接触压力和最大压缩应力。我们讨论了准确的，特定于任务的骨骼运动学在特定于主题的有限元建模的重要性，沿着简化假设和限制的影响。
In this paper, we present a new methodology for subject-specific finite element modeling of the tibiofemoral joint based on in vivo computed tomography (CT), magnetic resonance imaging (MRI), and dynamic stereo-radiography (DSX) data. We implemented and compared two techniques to incorporate in vivo skeletal kinematics as boundary conditions: one used MRI-measured tibiofemoral kinematics in a nonweight-bearing supine position and allowed five degrees of freedom (excluding flexion-extension) at the joint in response to an axially applied force; the other used DSX-measured tibiofemoral kinematics in a weight-bearing standing position and permitted only axial translation in response to the same force. Verification and comparison of the model predictions employed data from a meniscus transplantation study subject with a meniscectomized and an intact knee. The model-predicted cartilage-cartilage contact areas were examined against "benchmarks" from a novel in situ contact area analysis (ISCAA) in which the intersection volume between nondeformed femoral and tibial cartilage was characterized to determine the contact. The results showed that the DSX-based model predicted contact areas in close alignment with the benchmarks, and outperformed the MRI-based model: the contact centroid predicted by the former was on average 85% closer to the benchmark location. The DSX-based FE model predictions also indicated that the (lateral) meniscectomy increased the contact area in the lateral compartment and increased the maximum contact pressure and maximum compressive stress in both compartments. We discuss the importance of accurate, task-specific skeletal kinematics in subject-specific FE modeling, along with the effects of simplifying assumptions and limitations.