Influence of Neoadjuvant Chemotherapy on Short-term Outcomes After Minimally Invasive Esophagectomy for Esophageal Cancer
Influence of Neoadjuvant Chemotherapy on Short-term Outcomes After Minimally Invasive Esophagectomy for Esophageal Cancer
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DOI：
10.21873/anticanres.13136
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发表时间：
2019-01-01
影响因子：
2
通讯作者：
Baba, Hideo
中科院分区：
文献类型：
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作者：
Nomoto, Daichi;Yoshida, Naoya;Baba, Hideo
背景/目的：食管癌新辅助化疗（NAC）后行微创食管切除术（MIE）的安全性尚未得到充分证实。患者与方法：入组了2011年5月至2018年6月期间在熊本大学医院接受MIE治疗食管癌的212例患者。共有46例患者接受了NAC并接受了随后的MIE。对照组包括166例接受MIE的患者，术前未进行任何治疗。我们回顾性研究了两组患者的相关因素、肿瘤相关因素和手术相关因素，以及短期结果。结果如下：NAC + MIE组术前淋巴细胞计数、血红蛋白和白蛋白水平均显著低于MIE组。NAC加MIE组的术前营养状况（通过预后营养指数和控制营养状况来衡量）也较差（p
Background/Aim: The safety of minimally invasive esophagectomy (MIE) after neoadjuvant chemotherapy (NAC) for esophageal cancer has not been adequately confirmed. Patients and Methods: Two hundred and twelve patients who underwent MIE for esophageal cancer at the Kumamoto University Hospital between May 2011 and June 2018 were enrolled. A total of 46 patients received NAC and underwent subsequent MIE. The control group comprised 166 patients who underwent MIE without any preoperative treatments. We retrospectively investigated the patient-related, tumor-related, and surgery-related factors, as well as the short-term outcomes, between the two groups. Results: Preoperative lymphocyte counts and hemoglobin and albumin levels were significantly lower in the NAC plus MIE group than in the MIE alone group. Preoperative nutritional status, as measured by the prognostic nutrition index and controlling nutritional status, was also poorer in the NAC plus MIE group (p