Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis.
Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis.
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DOI：
10.4172/2155-9899.1000212
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发表时间：
2014-04-22
期刊：
影响因子：
--
通讯作者：
Cao W
中科院分区：
文献类型：
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作者：
Cao W
浆细胞样树突状细胞（pDC）最初被鉴定为在病毒感染期间主要的天然I型干扰素产生细胞。在过去的十年中，pDC响应于自身衍生的分子实体而异常产生干扰素α/β已经与系统性红斑狼疮的发病机制密切相关，并被认为是其他自身免疫性疾病的一般特征。除了对人pDC的迫切研究之外，最近已经从几种实验性狼疮模型的研究中揭示了pDC-干扰素α/β途径促进自身免疫进展的功能参与和机制。本文综述了从人类体外表征和小鼠体内研究中获得的相关信息，并强调了pDCs对系统性自身免疫表现发病机制的基本和多方面贡献。
Plasmacytoid dendritic cells (pDCs) were initially identified as the prominent natural type I interferon-producing cells during viral infection. Over the past decade, the aberrant production of interferon α/β by pDCs in response to self-derived molecular entities has been critically implicated in the pathogenesis of systemic lupus erythematosus and recognized as a general feature underlying other autoimmune diseases. On top of imperative studies on human pDCs, the functional involvement and mechanism by which the pDC-interferon α/β pathway facilitates the progression of autoimmunity have been unraveled recently from investigations with several experimental lupus models. This article reviews correlating information obtained from human in vitro characterization and murine in vivo studies and highlights the fundamental and multifaceted contribution of pDCs to the pathogenesis of systemic autoimmune manifestation.