NEW SYNTHESES OF PYRAZOLO[3,4-D]PYRIMIDINE, PYRAZOLO[3,4-D]PYRIDAZINE, ISOINDOLINEDIONE AND PYRAZOLE DERIVATIVES
NEW SYNTHESES OF PYRAZOLO[3,4-D]PYRIMIDINE, PYRAZOLO[3,4-D]PYRIDAZINE, ISOINDOLINEDIONE AND PYRAZOLE DERIVATIVES
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DOI：
10.1002/prac.19893310106
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
ABBAS, IM
中科院分区：
文献类型：
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作者：
ABDELHAMID, AO;NEGM, AM;ABBAS, IM
phenacylmalononnitril2与肼、乙酸-盐酸和重氮化伯胺反应，分别生成phenacylpyrazole （5a,b）、aminofurans （6a,b）和aminopyrazole衍生物（3a,d）。所合成的衍生物（3d, 6a）是合成异吲哚二酮、（7a-c）吡唑并吡啶（9,10）和吡唑并吡啶衍生物（11）的关键原料。新合成的杂环化合物除了通过其它途径合成外，还通过元素分析和光谱数据确定了其结构。
Phenacylmalononitriles2react with hydrazines, acetic‐hydrochloric acid and with diazotised primary aromatic amines to afford phenacylpyrazole (5a,b), aminofurans (6a,b) and aminopyrazole derivatives (3a,d) respectively. The synthesised derivatives (3d, 6a) were the key materials for the synthesis of isoindolinedione, (7a–c) pyrazolopyrimidine (9, 10), and pyrazolopyridazine derivatives (11). The structures of the newly synthesised heterocycles were established on the basis of elemental analyses and spectral data besides synthesis via other routes.