COMPARATIVE NEUROANATOMY OF THE HISTAMINERGIC SYSTEM IN THE BRAIN OF THE FROG XENOPUS-LAEVIS
COMPARATIVE NEUROANATOMY OF THE HISTAMINERGIC SYSTEM IN THE BRAIN OF THE FROG XENOPUS-LAEVIS
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DOI：
10.1002/cne.902920307
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发表时间：
1990-02-15
影响因子：
2.5
通讯作者：
PANULA, P
中科院分区：
文献类型：
--
作者：
AIRAKSINEN, MS;PANULA, P
组胺能神经元系统在爪蛙爪蟾脑中的分布映射与抗组胺固定组胺的抗血清，并在哺乳动物中进行了比较。组胺免疫反应阳性细胞体位于下丘脑后外侧的一个小区域，靠近背漏斗核，其中含有catecolamine能神经元和nitronergic神经元。这个区域可能与哺乳动物的结节乳头核同源。室管膜细胞层之间的细胞伸出一个粗突，终止于心室腔。与哺乳动物脑相比，成年非洲爪蟾脑中组胺能细胞体的数量相对较低。用抗GABA或5-羟色胺的抗血清染色的相邻切片的初步分析表明，组胺细胞对这些没有免疫反应性。非洲爪蟾脑内组胺能纤维的通路和分布与哺乳动物有许多相似之处。基底前脑内侧部，尤其是杏仁核内侧部和隔部，存在致密纤维网。一个明显的纤维簇集中在细胞体周围的丘脑核。在大多数苍白球区，密度为中等至低。在原始梨状皮质和纹状体中，很少看到纤维。在原始梨状皮质和纹状体中，很少看到纤维。在间脑，最高的纤维密度被发现在前和腹侧丘脑和后和外侧下丘脑。在后脑，密度最高的是在中央灰质的髓质，在一些哺乳动物。结果表明，脊椎动物脑中组胺能系统的一般模式是保守的，从两栖动物到哺乳动物。
The distribution of the histaminergic neuronal system in the brain of the clawed frog Xenopus laevis was mapped with an antiserum against carbodiimide-fixed histamine and compared to that in mammals. The histamine-immunoreactive cell bodies were located in a small area of the posterolateral hypothalamus, close to the dorsal infundibular nucleus, which contains catecolaminergic and serotonergic neurons. This area may be homologous to the tuberomammillary nucleus in mammals. A thick process extended from each cell between the ependymal cell layer and terminated in the ventricle lumen. The number of histaminergic cell bodies in adult Xenopus brain was relatively low, as compared with the mammalian brain. Preliminary analysis of the adjacent sections stained with antisera against GABA or serotonin indicated that the histamine cells were not immunoreactive for these. The pathways and distribution of histaminergic fibers in Xenopus brain showed many similarities to mammals. The densest fiber networks were present in the medial basal forebrain, particularly in the medial amygdala and septum. A distinct cluster of fibers was concentrated around the cell bodies of nucleus accumbens. In most pallial areas, the density was moderate to low. In the primordial piriform cortex and the striatum, very few fibers were seen. In the primordial piriform cortex and the striatum, very few fibers were seen. In diencephalon, highest fiber densities were found in the anterior and ventral thalamus and posterior and lateral hypothalamus. In hindbrain, the density was highest in the medullary central gray, as in some mammals. The results suggest that the general pattern of the histaminergic system in vertebrate brain is conserved from amphibians to mammals.