Endogenous Ligands for Nuclear Receptors: Digging Deeper*
Endogenous Ligands for Nuclear Receptors: Digging Deeper*
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DOI：
10.1074/jbc.r110.182451
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
M. Schupp;M. Lazar
中科院分区：
文献类型：
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作者：
M. Schupp;M. Lazar
核受体（NRs）是一种能将饮食或内分泌信号转化为基因表达变化的敏感转录因子。因此，通过鉴定其内源性配体来采用孤儿NR是我们理解其生物学的关键因素。本文综述了近年来过氧化物酶体增殖物激活受体α、γ、Rev-erbα及其相关受体的内源性配体的研究进展。关于这些配体的性质和生理学的知识可能为治疗药物开发创造新的机会。
Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs through the identification of their endogenous ligands is a key element for our understanding of their biology. In this minireview, we give an update on recent progress in regard to endogenous ligands for a cluster of NRs with high sequence homology, namely peroxisome proliferator-activated receptors α and γ, Rev-erbα, and related receptors. This knowledge about the nature and physiology of these ligands may create new opportunities for therapeutic drug development.