Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
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DOI：
10.1007/s10803-009-0794-4
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发表时间：
2009-11
影响因子：
3.9
通讯作者：
Hatchwell, Eli
中科院分区：
文献类型：
--
作者：
Gadow, Kenneth D.;Roohi, Jasmin;DeVincent, Carla J.;Kirsch, Sarah;Hatchwell, Eli
关键词：
该研究的目的是检测rs4680 （COMT）和rs6265 （BDNF）作为焦虑、多动症和抽搐的遗传标记。家长和老师完成了一份参考dsm - iv的评估量表，共67名自闭症谱系障碍（ASD）儿童。COMT （p = 0.06）和BDNF （p = 0.07）基因型对教师社交恐惧症评分均有统计学意义（ηp = 0.06）。分析还显示BDNF基因型与父母评定的ADHD （p = 0.01, ηp2 = 0.10）和教师评定的抽动症（p = 0.04, ηp2 = 0.07）相关。BDNF基因型与DAT1 3′VNTR与抽动严重程度可能存在交互作用（p = 0.02, ηp2 = 0.09）。BDNF和COMT可能是ASD表型变异的生物标志物，但这些初步发现仍有待于更大的独立样本的复制。
The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp2 = 0.10) and teacher-rated tics (p = 0.04; ηp2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp2 = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.
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DOI：
10.1097/00004583-200005000-00009
发表时间：
2000-05-01
影响因子：
13.3
作者：
Coffey, BJ;Biederman, J;Kim, GS
通讯作者：
Kim, GS
影响因子：
5.2
作者：
Gadow, KD;Devincent, CJ;Azizian, A
通讯作者：
Azizian, A
影响因子：
3.9
作者：
Gadow, Kenneth D.;DeVincent, Carla;Schneider, Jayne
通讯作者：
Schneider, Jayne
影响因子：
5.2
作者：
Gillott, A;Furniss, F;Walter, A
通讯作者：
Walter, A
影响因子：
17.7
作者：
Brune, Camille W.;Kim, Soo-Jeong;Cook, Edwin H., Jr.
通讯作者：
Cook, Edwin H., Jr.