Intramedullary pressure changes in rats after spinal cord injury
Intramedullary pressure changes in rats after spinal cord injury
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DOI：
10.1038/sc.2016.35
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发表时间：
2016-11-01
期刊：
影响因子：
2.2
通讯作者：
Zhang, H.
中科院分区：
文献类型：
--
作者：
Dong, X.;Yang, D.;Zhang, H.
目的：本研究的目的是探讨大鼠不同程度脊髓挫伤后髓内压随时间的变化，验证损伤越重髓内压越高的假说。方法：对照组大鼠仅进行椎板切除术，而三个实验组中的大鼠进行轻度，椎板切除术后中度或重度第10胸脊髓（T10）挫伤。此外，通过Millar Mikro-Tip压力导管测量T10的髓内压（Millar Incorporated Company，Houston，TX，USA），在对照组中立即或在实验组中在损伤后的不同时间点。对照组大鼠的平均髓内压为6.88 ± 1.67 mm Hg，而各损伤组大鼠均明显高于对照组（P= 0.000）。轻、中度损伤组不同时间点比较差异有统计学意义（P= 0.007/0.017），重度损伤组无统计学意义（P= 0.374）。轻、中度损伤组髓内压随时间的变化曲线呈双峰型，峰值出现在伤后1 h和48 h。脊髓损伤后髓内压与损伤程度呈正相关（r= 0.438，P= 0.000）。在损伤不严重的情况下，髓内压随时间波动，在伤后1和48 h达到峰值。如果损伤严重，髓内压仍然很高。损伤越严重，髓内压越高。
Objectives: The objectives of this study were to explore the change of intramedullary pressure over time in rats after different degrees of spinal cord contusion injury and to verify the hypothesis that the more serious the injury, the higher the intramedullary pressure.Methods: The control group rats underwent laminectomy only, whereas the rats in the three experimental groups were subjected to mild, moderate or severe 10th thoracic cord (T10) contusion injury after laminectomy. In addition, an intramedullary pressure of T10 was measured by a Millar Mikro-Tip pressure catheter (Millar Incorporated Company, Houston, TX, USA) immediately in the control group or at different time points after injury in the experimental groups.Results: The average intramedullary pressure of the rats in the control group was 6.88 +/- 1.67mm Hg, whereas that of the rats in any injury group was significantly higher (P= 0.000). There was statistical difference among the different time points in the mild or moderate injury group (P= 0.007/0.017), but no in the severe (P= 0.374). The curves of intramedullary pressure over time in the mild and moderate injury group were bimodal, peaking at 1 and 48 h after the injury. The intramedullary pressure after injury was positively correlated with the injury degree (r= 0.438, P= 0.000).Conclusions: The intramedullary pressure of the rats increased after traumatic spinal cord injury. If the injury was not serious, the intramedullary pressure fluctuated with time and peaked at 1 and 48 h after injury. If the injury was serious, the intramedullary pressure remained high. The more serious the injury, the higher the intramedullary pressure.