Regulation of collagen biosynthesis by ascorbic acid: a review.
Regulation of collagen biosynthesis by ascorbic acid: a review.
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发表时间：
1985-11
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通讯作者：
S. Pinnell
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作者：
S. Pinnell
l -抗坏血酸是胶原生物合成所必需的赖氨酸羟化酶和脯氨酸羟化酶的必需辅因子。此外，l -抗坏血酸优先刺激胶原合成的方式似乎与l -抗坏血酸对羟基化反应的影响无关。该反应具有立体特异性，与细胞内胶原蛋白降解无关。这种作用显然发生在转录或翻译水平，因为l -抗坏血酸优先刺激胶原特异性mRNA。此外，在培养的人皮肤成纤维细胞中，它刺激赖氨酸羟化酶活性，但抑制脯氨酸羟化酶活性。
L-ascorbic acid is an essential cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes essential for collagen biosynthesis. In addition, L-ascorbic acid preferentially stimulates collagen synthesis in a manner which appears unrelated to the effect of L-ascorbic acid on hydroxylation reactions. This reaction is stereospecific and unrelated to intracellular degradation of collagen. The effect apparently occurs at a transcriptional or translational level, since L-ascorbic acid preferentially stimulates collagen-specific mRNA. In addition, it stimulates lysyl hydroxylase activity but inhibits prolyl hydroxylase activity in human skin fibroblasts in culture.