Role of phosphoinositides in transmembrane signaling.
Role of phosphoinositides in transmembrane signaling.
复制标题
磷酸肌醇在跨膜信号传导中的作用。
DOI：
10.1152/physrev.1990.70.1.115
复制
发表时间：
1990
影响因子：
33.6
通讯作者：
Hokin,LE
中科院分区：
文献类型：
--
作者：
Rana,RS;Hokin,LE
近年来，人们对激动剂刺激的含肌醇磷脂的分解和周转产生了广泛的兴趣。尽管这些脂质占总细胞磷脂的<10%，但它们刺激的周转占总磷脂周转的相当高的百分比。磷酸肌醇领域目前是生物化学领域引用次数第一的领域（不包括分子生物学）。以一项摘要服务为基础，该领域发表的论文数量约为每月 150 篇或每天 5 篇。现在看来很清楚，磷酸肌醇效应是一种多调节机制，涉及母体分子各个部分的释放，这些部分作为第二信使，促进由多种激动剂激活受体引起的细胞中的无数变化。除了已确定的第二信使肌醇 1, 4, 5 三磷酸 (1, 4, 5-IP3) 和 L, Z-二酰基甘油 (DAG) 之外，越来越多的证据表明还有其他第二信使。关于这个主题的许多评论每月都会出现（例如，参见参考文献2、39、50、53、128、185,304,676,796），尽管最近它们倾向于关注磷酸肌醇反应的一个方面或一种细胞类型。在这篇评论中，我们试图涵盖该领域的大多数方面。我们希望这里提供的大量参考书目对新手和更有经验的研究者都有用。
In recent years, there has been widespread interest in the agonist-stimulated breakdown and turnover of myo-inositol-containing phospholipids. Although these lipids comprise< lo% of the total cellular phospholipid, their stimulated turnover accounts for a considerably higher percentage of total phospholipid turnover. The phosphoinositide field is currently the number one field in biochemistry in the number of citations (excluding molecular biology). On the basis of one abstract service, the number of papers published in this area is~ 150 papers per month or 5 papers per day. It now seems clear that the phosphoinositide effect is a multiregulatory mechanism involving the release of various moieties of the parent molecules, which serve as second messengers subserving myriad changes in the cell elicited by receptor activation by a wide variety of agonists. In addition to the well-established second messengers, inositol 1, 4, 5trisphosphate(1, 4, 5-IP3) and l, Z-diacylglycerol (DAG), evidence is mounting for additional second messengers. Numerous reviews on this subject are appearing monthly (eg, see Refs. 2, 39, 50, 53, 128, 185,304,676,796), although recently they have tended to focus on one aspect of the phosphoinositide response or one cell type. In this review, we tried to cover most aspects of the field. We hope that the extensive bibliography presented here may be useful for the neophyte as well as for the more experienced investigator.