Platelet-Rich Plasma and Platelet-Rich Fibrin Enhance the Outcomes of Fat Grafting: A Comparative Study
Platelet-Rich Plasma and Platelet-Rich Fibrin Enhance the Outcomes of Fat Grafting: A Comparative Study
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富含血小板的血浆和富含血小板的纤维蛋白增强脂肪移植的效果：一项比较研究
DOI：
10.1097/prs.0000000000005624
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发表时间：
2019-06-01
影响因子：
3.6
通讯作者：
Yi, Chenggang
中科院分区：
文献类型：
--
作者：
Xiong, Shaoheng;Qiu, Lihong;Yi, Chenggang
背景：自体脂肪移植是整形外科的一种有效方法。然而，其长期组织吸收是可变的，并依赖于技术。富血小板血浆对脂肪移植结果有积极影响，但仍然存在缺点，据报道富血小板纤维蛋白在脂肪移植中具有功效。在此，我们通过组织学分析比较了富血小板纤维蛋白和富血小板血浆在脂肪移植中的作用。方法：20只家兔随机分为两组。在每组中，将腹股沟区域脂肪垫切成1-mm 3的颗粒。富血小板纤维蛋白处理或富血小板血浆处理的脂肪颗粒被移植到一只耳朵，而对侧耳移植正常生理盐水处理的脂肪颗粒。脂肪移植后12周观察移植组织的组织学特征和毛细血管密度。结果如下：富血小板纤维蛋白治疗组的移植脂肪显示出比对照组更高的组织保留[体重保留，19.57（四分位数范围，13.87%至29.93%）与9.04%（四分位距6.16 ~ 16.80%），p < 0.05;体积保持率为18.00%（四分位数范围，10.50%至26.50%）与8.00%（四分位数范围，5.75%至13.25%），P < 0.05]和较高的新生血管化毛细血管密度。与对照组相比，富血小板血浆处理组显示出更高的血管密度，但没有上级组织保留。结论：与对照组相比，富血小板纤维蛋白增加了移植脂肪的组织保留、质量和血管化，并显示出与富血小板血浆对组织保留和组织学移植物改善相似的效果。
Background: Autologous fat grafting is an efficient procedure in plastic surgery. However, its long-term tissue absorption is variable and technique-dependent. Platelet-rich plasma positively affects fat-grafting outcomes but still has shortcomings, and platelet-rich fibrin has been reported to have efficacy in fat transplantation. Here, we compared the effects of platelet-rich fibrin and platelet-rich plasma in fat grafting using histologic analysis. Methods: Twenty rabbits were divided randomly into two groups. In each group, the groin region fat pads were cut into 1-mm3 granules. Platelet-rich fibrintreated or platelet-rich plasma-treated fat granules were transplanted into one ear, whereas the contralateral ear was transplanted with normal saline-treated fat granules. Histologic characteristics and capillary density of grafted tissue were analyzed 12 weeks after fat grafting. Results: The grafted fat in the platelet-rich fibrin-treated group showed higher tissue retention than that in the control group [ weight retention, 19.57 percent (interquartile range, 13.87 to 29.93 percent) versus 9.04 percent (interquartile range, 6.16 to 16.80 percent), p < 0.05; and volume retention, 18.00 percent (interquartile range, 10.50 to 26.50 percent) versus 8.00 percent (interquartile range, 5.75 to 13.25 percent), p < 0.05] and higher neovascularized capillary density than that in the platelet-rich plasma-treated and control groups. The platelet-rich plasma-treated group showed higher vessel density without superior tissue retention compared with the control group. Conclusion: Platelet-rich fibrin increased tissue retention, quality, and vascularization of grafted fat compared with the control group and showed effects similar to those of platelet-rich plasma on tissue retention and histologic graft improvement.