Death and the neurone
Death and the neurone
复制标题
死亡与神经元
DOI：
10.1038/284305a0
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发表时间：
1980
期刊：
影响因子：
64.8
通讯作者：
Julian Lewis
中科院分区：
文献类型：
--
作者：
Julian Lewis
神经发育的大问题表现在许多小谜团中。其中就有运动神经元死亡的现象。脊椎动物胚胎一开始会产生过量的运动神经元，大约在神经肌肉连接开始形成的时候，500个或更多的初始运动神经元通常会死亡。为什么会产生这些多余的细胞，是什么导致了它们的死亡？这种现象在几个系统中都有很好的记录，主要是在鸟类和两栖动物中，包括支配四肢的脊髓运动神经元，支配眼睛上斜肌的滑车运动神经元，以及支配固有眼肌的睫状神经节的副交感运动神经元(最近的综述见
THE great problems of neural development express themselves in many small mysteries. Among these is the phenomenon of motoneurone death. Vertebrate embryos generate at first an excess of motoneurones, and 500fo or more of the initial set normally die, round about the time when neuromuscular connections begin to form. Why are these surplus cells produced, and what causes their death? The phenomena are well-documented for several systems, chiefly in birds and amphibians, including the spinal motoneurones that innervate the limbs, the trochlear motoneurones that innervate the superior oblique muscle of the eye, and the parasympathetic motoneurones of the ciliary ganglion, which innervate the intrinsic eye muscles (for a recent review see