Oxidative aryl coupling reactions: a biomimetic approach to configurationally unstable or axially chiral biaryl natural products and related bioactive compounds
Oxidative aryl coupling reactions: a biomimetic approach to configurationally unstable or axially chiral biaryl natural products and related bioactive compounds
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DOI：
10.1016/s0040-4020(00)00940-6
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发表时间：
2001-01-07
期刊：
影响因子：
2.1
通讯作者：
Tasler, S
中科院分区：
文献类型：
--
作者：
Bringmann, G;Tasler, S
酚类和非酚类氧化芳基偶联反应已成功应用于联苯、双咔唑和双萘基异喹啉领域多种天然产物和相关化合物的高效合成。对于空间位阻较大的联芳基，因此显示出轴向手性现象，产物以阻转异构纯形式制备。它们的绝对轴向构型主要通过实验和计算CD研究来确定。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
Phenolic and non-phenolic oxidative aryl coupling reactions were successfully used in the efficient synthesis of diverse natural products and related compounds in the fields of biphenyls, biscarbazoles and bisnaphthylisoquinolines. For sterically more hindered biaryls, which consequently show the phenomenon of axial chirality, the products were prepared in an atropisomerically pure form. Their absolute axial configurations were assigned mainly by experimental and computational CD investigations. (C) 2000 Elsevier Science Ltd. All rights reserved.