Residential exposure to urban traffic is associated with increased carotid intima-media thickness in children.
Residential exposure to urban traffic is associated with increased carotid intima-media thickness in children.
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DOI：
10.1155/2015/713540
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发表时间：
2015
影响因子：
--
通讯作者：
Berwick M
中科院分区：
文献类型：
--
作者：
Armijos RX;Weigel MM;Myers OB;Li WW;Racines M;Berwick M
长期暴露于城市交通污染被证明会促进成年人的动脉粥样硬化，但对其在儿童中的潜在影响知之甚少。我们的研究调查了287名健康儿童长期暴露于交通与颈动脉内膜中层厚度（cIMT）的关系。住宅邻近度和距离加权交通密度（DWTD）被用作交通相关的空气污染暴露的邻近标记。多变量分析显示，居住在距离最近的交通繁忙道路<100米的儿童的cIMT平均值和最大值测量值比居住在≥ 200米的儿童增加了15%和11%（P = 0.0001）。在最高与最低DWTD三分位数的儿童中发现了类似的cIMT增加。居住在距离交通100-199米或中间DWTD三分位数的儿童也表现出cIMT增加，但这些差异无统计学意义。住宅距离交通或DWTD和全身炎症指标（CRP，IL-6）之间没有统计学显著差异。研究结果表明，暴露于城市交通促进儿童动脉重塑。这一发现很重要，因为即使cIMT随时间的微小增加也可能导致动脉粥样硬化的早期进展。这一点也很重要，因为与交通有关的污染是可以改变的。
Chronic exposure to urban traffic pollution is documented to promote atherosclerosis in adults but little is known about its potential effects in children. Our study examined the association of long-term exposure to traffic with carotid intima-media thickness (cIMT) in 287 healthy children. Residential proximity and distance-weighted traffic density (DWTD) were used as proximity markers for traffic-related air pollution exposure. The multivariable analyses revealed that children residing <100 meters from the nearest heavily trafficked road had cIMT mean and maximum measurements that were increased by 15% and 11% compared to those living ≥ 200 meters away (P = 0.0001). Similar increases in cIMT were identified for children in the highest versus lowest DWTD tertile. Children who resided 100–199 meters from traffic or in the middle DWTD tertile also exhibited increased cIMT but these differences were not statistically significant. No statistically significant differences were identified between residential distance to traffic or DWTD and systemic inflammation indicators (CRP, IL-6). The study results suggest that exposure to urban traffic promotes arterial remodeling in children. This finding is important since even small increases in cIMT over time can potentially lead to earlier progression to atherosclerosis. It is also important because traffic-related pollution is potentially modifiable.