Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts.
Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts.
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DOI：
10.1161/01.cir.101.9.1060
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发表时间：
2000-03
期刊：
影响因子：
37.8
通讯作者：
K. Yoshioka;D. Gao;M. Chin;C. Stillson;E. Penades;M. Lesh;W. O'Connell;M. Dae
中科院分区：
文献类型：
--
作者：
K. Yoshioka;D. Gao;M. Chin;C. Stillson;E. Penades;M. Lesh;W. O'Connell;M. Dae
交感神经支配的异质性被认为是导致致命性心律失常的潜在因素。然而，很少有人知道的异质神经支配复极的影响。方法和结果为了评估这种关系，我们测量了激活恢复时间（阿里斯）从64个心外膜部位在11只兔子研究2周后，由苯酚和4个假手术兔产生的区域去神经。将ARI结果与[（125）I]间碘苄胍和（99 m）Tc-司他米比系列放射自显影的3D重建测量的交感神经支配分布进行比较。在基线窦性心律、去甲肾上腺素（NE）输注（0.1 μ g. kg（-1）。min（-1））和左侧星状神经节刺激（SS）。NE缩短ARI在98%的电极在失神经区域。随着失神经程度的加重，ARI缩短程度和离散度增加（分别为P<0.001和P<0.01）。SS使失神经区30%的电极ARI缩短，缩短和离散度随失神经程度增加而增加（P<0.01）。SS延长ARI在70%的电极在失神经支配的地区，与失神经支配的严重程度没有相关性。结论：局部复极反应的幅度和离散度与失神经支配的严重程度以及刺激的类型有关：神经刺激（SS）与体液刺激（NE）。这种差异可能与释放NE的浓度有关。
BACKGROUND Heterogeneity of sympathetic innervation is thought to contribute to the potential for fatal arrhythmia. However, little is known about the effects of heterogeneous innervation on repolarization. METHODS AND RESULTS To assess this relationship, we measured activation recovery intervals (ARIs) from 64 epicardial sites in 11 rabbits studied 2 weeks after regional denervation produced by phenol and 4 sham-operated rabbits. ARI results were compared with the distribution of sympathetic innervation measured from 3D reconstructions of serial autoradiographs of [(125)I]metaiodobenzylguanidine and (99m)Tc-sestamibi. ARIs were recorded during baseline sinus rhythm, norepinephrine (NE) infusion (0.1 microg. kg(-1). min(-1)), and left stellate ganglion stimulation (SS). NE shortened ARI in 98% of electrodes in the denervated region. The degree of ARI shortening and dispersion increased (P<0.001 and P<0.01, respectively) as denervation became more severe. SS shortened ARI in 30% of electrodes in the denervated area, with increased shortening and dispersion related to increased severity of denervation (P<0.01). SS prolonged ARI in 70% of electrodes in the denervated area, with no correlation with severity of denervation. CONCLUSIONS The magnitude and dispersion of local repolarization responses are related to the severity of denervation, as well as the type of stimulation: neural (SS) versus humoral (NE). The differences may relate to the concentration of NE released.