GROWTH IN CHILDREN AFTER BONE-MARROW TRANSPLANTATION FOR ADVANCED NEUROBLASTOMA COMPARED WITH GROWTH AFTER TRANSPLANTATION FOR LEUKEMIA OR APLASTIC-ANEMIA
GROWTH IN CHILDREN AFTER BONE-MARROW TRANSPLANTATION FOR ADVANCED NEUROBLASTOMA COMPARED WITH GROWTH AFTER TRANSPLANTATION FOR LEUKEMIA OR APLASTIC-ANEMIA
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DOI：
10.1016/s0022-3476(05)80235-5
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发表时间：
1992-05-01
影响因子：
5.1
通讯作者：
MOSHANG, T
中科院分区：
文献类型：
--
作者：
WILLI, SM;COOKE, K;MOSHANG, T
对1978年至1988年间在费城儿童医院接受大剂量化疗、全身照射和骨髓移植治疗的26例进展期和进展期神经母细胞瘤儿童的直线生长与33例白血病移植和12例再生障碍性贫血移植的儿童进行了比较。接受骨髓移植治疗神经母细胞瘤的儿童的平均生长速度，以标准差分数表示，为-2.83。这显著(p<；0.005)低于急性淋巴细胞白血病、急性非淋巴细胞白血病和再生障碍性贫血接受移植的儿童的标准差分数，分别为-0.98%、-0.07%和-1.05%。一项对32名癌症长期幸存者的6年随访研究显示，11名神经母细胞瘤患者继续生长不良，而21名白血病骨髓移植幸存者的对照组在手术后2年基本正常生长。两组之间的主要治疗差异包括局部放射治疗的剂量以及使用的细胞毒药物的类型和数量。与白血病和再生障碍性贫血的制备方案对生长的抑制作用相对较轻相比，神经母细胞瘤患者使用的非常密集的制备方案对生长有显著的负面影响。
The linear growth of 26 children with progressive and advanced neuroblastoma treated with high-dose chemotherapy, total body irradiation, and bone marrow transplantation between 1978 and 1988 at the Children's Hospital of Philadelphia was compared with the growth of 33 children who had transplants for leukemia and of 12 who had transplants for aplastic anemia. The mean growth velocity, expressed as a standard deviation score, for the children who underwent bone marrow transplantation for neuroblastoma was -2.83. This was significantly (p < 0.005) less than the standard deviation scores for children with transplants for acute lymphoblastic leukemia, acute nonlymphocytic leukemia, and aplastic anemia, which were -0.98, -0.07, and -1.05, respectively. A 6-year follow-up study of 32 long-term survivors of cancer revealed that the 11 patients with neuroblastoma continued to grow poorly, whereas a comparison group of 21 survivors of bone marrow transplantation for leukemia had essentially normal growth 2 years after the procedure. Major therapeutic differences between the two groups included the doses of local radiotherapy and the type and number of cytotoxic agents used. In comparison with the relatively mild growth-inhibiting effects of preparative regimens for leukemia and aplastic anemia, the very intensive preparative regimens used in patients with neuroblastoma have significant negative effects on growth.