Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease.
Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease.
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DOI：
10.1155/2012/231502
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发表时间：
2012
影响因子：
--
通讯作者：
Girelli D
中科院分区：
文献类型：
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作者：
Martinelli N;Micaglio R;Consoli L;Guarini P;Grison E;Pizzolo F;Friso S;Trabetti E;Pignatti PF;Corrocher R;Olivieri O;Girelli D
低浓度的血浆高密度脂蛋白（HDL）是代谢综合征（MS）的特征。HDL的抗氧化能力至少部分归因于多效性血清对氧磷酶（PON 1）。在293名患有或不患有MS（n = 88）和患有或不患有经血管造影证实的冠状动脉疾病（CAD）（n = 195）的受试者中评估了不同的PON 1活性。MS受试者的PON 1活性较低，随着MS异常数量的增加，PON 1活性呈逐渐降低的趋势。相对于7-O-二乙基磷酰基，3-氰基，4-甲基，7-羟基香豆素（DEPCyMC）（被认为是PON 1浓度的替代标志物）的活性显示出与MS最显著的相关性，与HDL和载脂蛋白A-I水平无关。MS和低DEPCyMCase活性的受试者具有最高的CAD风险（OR 4.34，95%CI 1.44-13.10），而MS但高DEPCyMCase活性的受试者中未发现风险显著增加（OR 1.45，95%CI 0.47-4.46）。我们的研究结果表明，低PON 1浓度是典型的MS，并可能调节MS相关的CAD风险。
Low concentrations of plasma high-density lipoprotein (HDLs) are characteristic in metabolic syndrome (MS). The antioxidant ability of HDLs is, at least in part, attributable to pleiotropic serum paraoxonase (PON1). Different PON1 activities have been assessed in 293 subjects with (n = 88) or without MS (n = 205) and with (n = 195) or without (n = 98) angiographically proven coronary artery disease (CAD). MS subjects had low PON1 activities, with a progressively decreasing trend by increasing the number of MS abnormalities. The activity versus 7-O-diethyl phosphoryl,3-cyano,4-methyl,7-hydroxycoumarin (DEPCyMC), which is considered a surrogate marker of PON1 concentration, showed the most significant association with MS, independently of both HDL and apolipoprotein A-I levels. Subjects with MS and low DEPCyMCase activity had the highest CAD risk (OR 4.34 with 95% CI 1.44–13.10), while no significant increase of risk was found among those with MS but high DEPCyMCase activity (OR 1.45 with 95% CI 0.47–4.46). Our results suggest that low PON1 concentrations are typical in MS and may modulate the MS-related risk of CAD.