COMPARISON OF DEXMEDETOMIDINE AND MIDAZOLAM SEDATION AND ANTAGONISM OF DEXMEDETOMIDINE WITH ATIPAMEZOLE
COMPARISON OF DEXMEDETOMIDINE AND MIDAZOLAM SEDATION AND ANTAGONISM OF DEXMEDETOMIDINE WITH ATIPAMEZOLE
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DOI：
10.1016/0952-8180(93)90014-6
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发表时间：
1993-05-01
影响因子：
6.7
通讯作者：
KORTTILA, K
中科院分区：
文献类型：
--
作者：
AHO, M;ERKOLA, O;KORTTILA, K
Study Objective: To evaluate the effects of dexmedetomidine, an alpha-2 agonist, as an intravenous sedative drug and the effects of atipamezole, an alpha-2 antagonist, on recovery.Design: Randomized, double-blind study with three parallel groups. An open dose-finding study preceded it to optimize the atipamezole dose.Setting: Outpatient operating room at the gynecologic and obstetric university hospital in Helsinki, Finland.Patients: Seventy-two healthy women scheduled for legal termination of pregnancy.Interventions: Patients were assigned to one of three groups of 24 patients each to receive either dexmedetomidine 2 mug/kg and atipamezole 50 mug/kg; dexmedetomidine 2 mug/kg and saline; or midazolam 0.15 mg/kg and saline. In addition to paracervical block, each patient received two different study drugs: study drug 1 was a sedative agent (either dexmedetomidine or midazolam), administered before the procedure. If the sedation was not deep enough and the patient reacted to the procedure, a low dose of propofol was administered. Study drug 2 was a reversing agent or a placebo, administered following the procedure.Measurements and Main Results: The mean time to regain consciousness was shorter in the dexmedetomidine-atipamezole and the dexmedetomidine-saline groups compared with the midazolam group. Postoperative sedation, tested both by subjective and objective assessments, decreased more quickly in the dexmedetomidine-atipamezole group compared with the dexmedetomidine-saline and the midazolam groups.Conclusion: Atipamezole is an effective antagonist for reversing psychomotor impairment following dexmedetomidine sedation.
