STUDIES ON AMINO ACID METABOLISM .3. PLASMA GLYCINE CONCENTRATION AND HIPPURIC ACID FORMATION FOLLOWING THE INGESTION OF BENZOATE
STUDIES ON AMINO ACID METABOLISM .3. PLASMA GLYCINE CONCENTRATION AND HIPPURIC ACID FORMATION FOLLOWING THE INGESTION OF BENZOATE
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DOI：
10.1172/jci102014
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发表时间：
1948-01-01
影响因子：
15.9
通讯作者：
ALEXANDER, B
中科院分区：
文献类型：
--
作者：
DEVRIES, A;ALEXANDER, B
广告。在11例患者中，有10例患者的血浆甘氨酸浓度下降。广告。与单独摄入苯甲酸酯相比，在服用苯甲酸酯之前或与之一起摄入甘氨酸会导致更多的马尿酸产量。甘氨酸与苯甲酸的结合率、甘氨酸的可获得性以及苯甲酸的剂量大小，是影响人体合成马尿酸的重要因素。
The admn. of Na benzoate resulted, in 10 of 11 expts., in a decrease in plasma glycine concn. The admn. of glycine before or together with the benzoate resulted in a larger output of hippuric acid than when benzoate alone was ingested. The rate of conjugation of glycine to benzoate, the availability of glycine for this purpose, and the size of the dose of benzoate, are important factors which affect hippuric acid synthesis in man.