Enhanced adhesion of osteoblastic cells on polystyrene films by independent control of surface topography and wettability
Enhanced adhesion of osteoblastic cells on polystyrene films by independent control of surface topography and wettability
复制标题
DOI：
10.1016/j.msec.2012.12.081
复制
发表时间：
2013-04-01
影响因子：
7.9
通讯作者：
Kim, Jin Ron
中科院分区：
文献类型：
--
作者：
Yang, Seung Yun;Kim, Eung-Sam;Kim, Jin Ron
我们独立控制的表面形貌和润湿性的聚苯乙烯（PS）薄膜的CF4和氧等离子体处理，分别评估人胎儿成骨细胞（hFOB）的膜上的粘附和增殖。在平均表面粗糙度为0.9至70 nm的CF4等离子体处理的PS膜中，在粗糙度类似于11 nm的PS膜上观察到hFOB细胞的最高粘附。当该膜另外通过氧等离子体处理以提供接触角小于10度的亲水表面时，骨形成细胞的增殖进一步增强。因此，基于等离子体的PS膜的独立改性为人成骨细胞的最佳纳米织构可应用于骨组织工程材料。(C)2012爱思唯尔有限公司版权所有。
We independently controlled surface topography and wettability of polystyrene (PS) films by CF4 and oxygen plasma treatments, respectively, to evaluate the adhesion and proliferation of human fetal osteoblastic (hFOB) cells on the films. Among the CF4 plasma-treated PS films with the average surface roughness ranging from 0.9 to 70 nm, the highest adhesion of hFOB cells was observed on a PS film with roughness of similar to 11 nm. When this film was additionally treated by oxygen plasma to provide a hydrophilic surface with a contact angle less than 10 degrees, the proliferation of bone-forming cell was further enhanced. Thus, the plasma-based independent modification of PS film into an optimum nanotexture for human osteoblast cells could be appplied to materials used in bone tissue engineering. (C) 2012 Elsevier B.V. All rights reserved.