Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis
Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis
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DOI：
10.1253/circj.68.1
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发表时间：
2004-01-01
影响因子：
3.3
通讯作者：
Fukuda, N
中科院分区：
文献类型：
--
作者：
Soeki, T;Tamura, Y;Fukuda, N
背景血管内皮钙粘蛋白（VE-cadherin）是一种钙离子依赖性细胞粘附分子，在动脉粥样硬化病变中由内皮细胞表达，并与新生血管形成有关，方法和结果测定外周血中VE-钙粘蛋白的浓度，并与冠状动脉粥样硬化性心脏病（CHD）进行相关性分析。对24例急性心肌梗死（AMI）、26例稳定型心绞痛（AP）、18例陈旧性心肌梗死（OMI）患者和30例冠状动脉造影无狭窄的对照者（Control）的股动脉和冠状静脉窦进行了对比研究。对于AMI患者，在急性期（第1天）和慢性期（第21天）采集血样。采用酶联免疫吸附法测定血浆VE-钙粘蛋白浓度。血浆VE-钙粘蛋白浓度和Gensini评分之间的相关性也被确定为冠状动脉粥样硬化严重程度的指标。AMI、AP和OMI患者外周血和冠状静脉窦血中VE-钙粘蛋白浓度（ng/ml）均高于对照组，而3组冠心病患者之间无显著差异（股动脉：AMI 5.1 +/- 2.5，AP 4.7 +/- 2.4，OMI 4.5 +/- 3.3，对照组2.6 +/- 2.3;冠状窦：AMI 5.6 +/- 2.6，AP 5.0 +/- 2.3，OMI 5.0 +/- 2.9，对照2.4 +/- 2.1）。AMI患者冠状静脉窦VE-钙粘蛋白浓度高于外周血（p
Background Vascular endothelial (VE)-cadherin, a Ca2+-dependent cell adhesion molecule, is expressed in atherosclerotic lesions by endothelial cells and is associated with neovascularization, although the relationship between circulating VE-cadherin and coronary artery disease has not been studied.Methods and Results The plasma concentration of VE-cadherin was measured in peripheral blood (femoral artery) and the coronary sinus of 24 patients with acute myocardial infarction (AMI), 26 with stable angina pectoris (AP), 18 with old myocardial infarction (OMI), and 30 control subjects (Control) who had no coronary artery stenosis on angiography. For the patients with AMI, blood samples were obtained in the acute (day 1) and chronic (day 21) phases. The plasma concentration of VE-cadherin was measured by enzyme-linked immunosorbent assay. The correlation between the plasma VE-cadherin concentration and the Gensini score was also determined as an index of the severity of coronary atherosclerosis. The plasma concentrations of VE-cadherin (ng/ml) in both the peripheral and coronary sinus blood were higher in patients with AMI, AP, and OMI than in the control subjects, and were similar in the 3 groups with coronary artery disease (femoral artery: AMI 5.1 +/- 2.5, AP 4.7 +/- 2.4, OMI 4.5 +/- 3.3, Control 2.6 +/- 2.3; coronary sinus: AMI 5.6 +/- 2.6, AP 5.0 +/- 2.3, OMI 5.0 +/- 2.9, Control 2.4 +/- 2.1, respectively). Plasma VE-cadherin concentrations were higher in the coronary sinus than peripheral blood samples in patients with AMI (p