Hypertension and multiple cardiovascular risk factors increase the risk for retinal vein occlusions: results from the Gutenberg Retinal Vein Occlusion Study
Hypertension and multiple cardiovascular risk factors increase the risk for retinal vein occlusions: results from the Gutenberg Retinal Vein Occlusion Study
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DOI：
10.1097/hjh.0000000000002057
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发表时间：
2019-07-01
影响因子：
4.9
通讯作者：
Mirshahi, Alireza
中科院分区：
文献类型：
--
作者：
Ponto, Katharina A.;Scharrer, Inge;Mirshahi, Alireza
目的：虽然视网膜静脉阻塞（RVO）的几个危险因素是已知的，在许多情况下，什么触发RVO是不清楚的。我们的目的是评估与RVO.Methods患者的多个危险因素的相关性：古滕贝格RVO研究是一项观察性病例对照研究，评估血栓性，心血管，眼科和药物相关的危险因素参与RVO和相同数量的匹配对照。结果：92例RVO患者中，中心型RVO 46例（50%），分支型RVO 31例（33.7%），半侧RVO 15例（16.3%）。系统性高血压与RVO相关[任何RVO：比值比（OR）：1.81; 95%置信区间（CI）：1.14-2.88;分支RVO：OR：2.56; 95% CI：1.08-6.10]。最常见的风险因素组合是高血压伴血脂异常（33/92，35.9%）和高同型半胱氨酸血症和高水平因子VIII（10/92，10.9%）。风险总和评分增加一个额外的风险因素对应的OR为1.74（95% CI：1.31-2.32）心血管危险因素，1.38（95% CI：1.04-1.82），对于嗜血栓性风险因素，（95% CI：1.20-1.70）。结论：心血管危险因素对RVO的发生具有重要意义。RVO的风险增加了约40%与任何额外的风险因素和70%与任何额外的心血管风险因素。
Objective: Although several risk factors for retinal vein occlusion (RVO) are known, what triggers RVO is unclear in many cases. We aimed to evaluate the relevance of multiple risk factors in patients with RVO.Methods: The Gutenberg RVO Study is an observational case-control study that assessed thrombophilic, cardiovascular, ophthalmic, and drug-related risk factors in participants with RVO and the same number of matched controls. Conditional logistic regression analysis was chosen to estimate the risk of RVO due to several risk factors.Results: Of 92 patients with RVO, 46 (50%) had central RVO, 31 (33.7%) had branch RVO, and 15 (16.3) had hemi-RVO. Systemic hypertension was associated with RVO [any RVO: odds ratio (OR): 1.81; 95% confidence interval (CI): 1.14-2.88; branch RVO: OR: 2.56; 95% CI: 1.08-6.10]. The most frequent combinations of risk factors were hypertension with dyslipidemia (33 of 92, 35.9%) and hyperhomocysteinemia and high levels of factor VIII (10 of 92, 10.9%). An increase in the risk sum score by one additional risk factor corresponded to ORs of 1.74 (95% CI: 1.31-2.32) for cardiovascular risk factors, 1.38 (95% CI: 1.04-1.82) for thrombophilic risk factors, and 1.43 (95% CI: 1.20-1.70) for the total number of risk factors for RVO.Conclusion: Cardiovascular risk factors are more important than other risk factors for the presence of RVO. The risk of RVO increased by approximately 40% with any additional risk factor and by 70% with any additional cardiovascular risk factor.