Climate-dependent genetic variation of alpha-2HS-glycoprotein.
Climate-dependent genetic variation of alpha-2HS-glycoprotein.
复制标题
α-2HS-糖蛋白的气候依赖性遗传变异。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
W. Kuchheuser
中科院分区：
文献类型：
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作者：
V. Spitsyn;O. Kravchuk;S. D. Nurbaev;D. Krause;W. Kuchheuser
我们研究了气候因素对决定人类 α2-HS-糖蛋白 (AHSG) 表型的等位基因的世界分布的可能影响。介绍了俄罗斯某些族群 AHSG 多态性的新数据。使用世界上 AHSG 基因频率分布的所有可用数据（人口数 n = 51）来分析 AHSG*2 等位基因频率与七个气候地理参数之间可能的相关性。 AHSG*2 等位基因频率与研究人群居住地区的地理纬度之间存在很强的正相关性 (r = 0.814)。世界上 AHSG*2 等位基因分布对紫外线辐射强度 (400-315 nm) 的依赖性估计为 r = -0.826。事实证明，日照总量和年平均气温等气候特征对 AHSG*2 等位基因频率的变化有同等贡献（r 分别为 -0.683 和 -0.658）。构建了北半球旧世界人群中 AHSG*2 等位基因分布的计算机制图模型。
We studied the possible effects of climatic factors on the world distribution of alleles determining alpha 2-HS-glycoprotein (AHSG) phenotypes in human populations. New data on AHSG polymorphism in certain ethnic groups of Russia are presented. All available data on the distribution of AHSG gene frequencies in the world (number of populations n = 51) were used to analyze possible correlations between AHSG*2 allele frequencies and seven climatic-geographic parameters. A strong positive correlation was found between AHSG*2 allele frequency and geographic latitude of territories inhabited by the study populations (r = 0.814). The dependence of the AHSG*2 allele distribution in the world on the intensity of ultraviolet radiation (400-315 nm) was estimated at r = -0.826. Such climatic characteristics as the total amount of insolation and the average annual temperature proved to make equal contributions to variation in AHSG*2 allele frequency (r = -0.683 and -0.658, respectively). A computer cartographic model of the AHSG*2 allele distribution in the Old World populations of the Northern Hemisphere was constructed.